Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Fish and Richardson
Johnson and Johnson

Generated: May 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,684,164

« Back to Dashboard

Title: Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
Abstract:Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
Inventor(s): Belleau, deceased; Bernard (late of Westmount, CA), Mansour; Tarek (Montreal, CA), Tse; Allan (Ville St-Laurent, CA), Evans; Colleen A. (Montreal, CA), Jin; Haolun (Pierrefonds, CA), Zacharie; Boulos (Laval des Rapides, CA), Nguyen-Ba; Nghe (La Prairie, CA)
Assignee: BioChem Pharma Inc. (Laval, CA)
Filing Date:Jun 06, 1995
Application Number:08/468,548
Claims:1. An intermediate useful in the production of oxathiolane compounds, said intermediate selected from the group consisting of:



trans-2-benzoyloxymethyl-5-hydroxy-1,3-oxathiolane, and mixtures thereof; and


trans-2-benzoyloxymethyl-5-acetoxy-1,3-oxathiolane, and mixtures thereof.

2. An intermediate useful in the production of oxathiolane compounds, said intermediate selected from the group consisting of:

cis-2-benzoyloxymethyl-5-(4',5'-dichlorobenzoyloxy)-1,3-oxathiolane, trans-2-benzoyloxymethyl-5-(4',5'-dichlorobenzoyloxy)-1,3-oxathiolane, and mixtures thereof;

cis-2-benzoyloxymethyl-5-trimethylacetoxy-1,3-oxathiolane, trans-2-benzoyloxymethyl-5-trimethylacetoxy-1,3-oxathiolane, and mixtures thereof;

cis-2-benzoyloxymethyl-5-(2',2',2'-trichloroethoxycarbonyloxy)-1,3-oxathiol ane, trans-2-benzoyloxymethyl-5-(2',2',2'-trichloroethoxycarbonyloxy)-1,3-oxath iolane, and mixtures thereof;

cis-2-benzoyloxymethyl-5-(ethoxycarbonyloxy)-1,3-oxathiolane, trans-2-benzoyloxymethyl-5-ethoxycarbonyloxy-1,3-oxathiolane, and mixtures thereof; and

cis-2-benzoyloxymethyl-5-(methoxycarbonyloxy)-1,3-oxathiolane, trans-2-benzoyloxymethyl-5-methoxycarbonyloxy-1,3-oxathiolane, and mixtures thereof.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Harvard Business School
Johnson and Johnson
Chinese Patent Office
Express Scripts

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.