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Details for Patent: 5,683,990

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Details for Patent: 5,683,990

Title: Treatment of human viral infections
Abstract:Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose. Additionally, there is disclosed the treatment of Kaposi's sarcoma with 3'-azido-3'-deoxythymidine (AZT) and the synergistic activity in the treatment of humans infected with HTLV-III of AZT and interferon as well as AZT and acyclovir and AZT and 2-amino-9-(2-hydroxyethoxymethyl)purine or an ester thereof.
Inventor(s): Rideout; Janet Litster (Raleigh, NC), Barry; David Walter (Chapel Hill, NC), Lehrman; Sandra Nusinoff (Durham, NC), St. Clair; Martha Heider (Durham, NC), Furman; Phillip Allen (Durham, NC)
Assignee: Glaxo Wellcome Inc. (Research Triangle Park, NC)
Filing Date:Aug 21, 1986
Application Number:06/899,079
Claims:1. A method of treating a human being who has been diagnosed as being infected with HTLV-III comprising the administration of a non-toxic, effective amount of a combination of 3'-azido-3'-deoxythymidine or its 5'-mono-, 5'-di-, or 5'-triphosphate, or a pharmaceutically acceptable salt thereof, and the compound of formula V. ##STR5## where R is H or ##STR6## wherein R.sup.0 is H, C.sub.1-16 alkyl and physiologically acceptable acid addition salts thereof.

2. The method of claim 1 in which the combination is 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt thereof and 2-amino-9-(2-hydroxyethoxymethyl)purine or a pharmaceutically acceptable acid addition salt thereof.

3. The method of claim 1 in which R is ##STR7## and R.sup.0 is C.sub.1-6 alkyl or hydrogen and the compound of formula V or salt thereof is in combination with the 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt thereof.

4. A method of treating a human being who has been diagnosed as being infected with HTLV-III comprising the administration of 3'-azido-3'-deoxythymidine and 2-amino-9- (2-hydroxyethoxymethyl) purine to said human being.
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