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|Title:||High affinity PDGF nucleic acid ligands|
|Abstract:||Methods are described for the identification and preparation of high-affinity nucleic acid ligands to PDGF. Included in the invention are specific ssDNA and RNA ligands to PDGF identified by the SELEX method.|
|Inventor(s):||Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO)|
|Assignee:||NeXstar Pharmaceuticals, Inc. (Boulder, CO)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. A purified and isolated non-naturally occurring nucleic acid ligand to PDGF. |
2. The purified and isolated non-naturally occurring nucleic acid ligand of claim 1 wherein said nucleic acid ligand is single-stranded.
3. The purified and isolated non-naturally occurring nucleic acid ligand of claim 2 wherein said nucleic acid ligand is RNA.
4. The purified and isolated non-naturally occurring nucleic acid ligand of claim 2 wherein said nucleic acid ligand is DNA.
5. A nucleic acid ligand to Platelet Derived Growth Factor (PDGF) identified according to the method comprising:
a) contacting a candidate mixture of nucleic acids with PDGF, wherein nucleic acids having an increased affinity to PDGF relative to the candidate mixture may be partitioned from the remainder of the candidate mixture;
b) partitioning the increased affinity nucleic acids from the remainder of the candidate mixture; and
c) amplifying the increased affinity nucleic acids to yield a mixture of nucleic acids enriched for nucleic acid sequences with relatively higher affinity and specificity for binding to PDGF, whereby a nucleic acid ligand of PDGF may be identified.
6. The purified and isolated non-naturally occurring RNA ligand to PDGF of claim 3 wherein said ligand is selected from the group consisting of the sequences set forth in Table 5 (SEQ ID NOS: 39-81).
7. The purified and isolated non-naturally occurring DNA ligand to PDGF of claim 4 wherein said ligand is selected from the group consisting of the sequences set forth in Table 2 (SEQ ID NOS: 4-35).
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