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|Title:||Use of the R-enantiomers of N-propargyl-1-aminoindan compounds for the treatment of depression|
|Abstract:||This invention relates to the use of R(+)-N-propargyl-1-aminoindan.|
|Inventor(s):||Youdim; Moussa B. H. (Haifa, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Berger-Paskin; Tirtsah (Raanana, IL), Yellin; Haim (Ramat-Gan, IL)|
|Assignee:||Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) Techion Research and Development Foundation Ltd. (Haifa, IL)|
|Filing Date:||Jun 02, 1995|
|Claims:||1. A method of treating a subject for depression, which comprises administering to the subject a pharmaceutical composition consisting essentially of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof in an amount effective to treat the subject and a carrier. |
2. The method of claim 1, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered orally or rectally.
3. The method of claim 2, wherein the amount administered is 2 to 20 mg per daily dosage unit.
4. The method of claim 3, wherein the amount administered is 5 to 10 mg per daily dosage unit.
5. The method of claim 1, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered parenterally.
6. The method of claim 5, wherein the amount administered is 1 to 10 mg per mL per daily dosage unit.
7. The method of claim 6, wherein the amount administered is 2 to 5 mg per mL per daily dosage unit.
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