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Details for Patent: 5,668,181

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Details for Patent: 5,668,181

Title: Use of the R-enantiomers of N-propargyl-1-aminoindan compounds for the treatment of depression
Abstract:This invention relates to the use of R(+)-N-propargyl-1-aminoindan.
Inventor(s): Youdim; Moussa B. H. (Haifa, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Berger-Paskin; Tirtsah (Raanana, IL), Yellin; Haim (Ramat-Gan, IL)
Assignee: Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) Techion Research and Development Foundation Ltd. (Haifa, IL)
Filing Date:Jun 02, 1995
Application Number:08/458,645
Claims:1. A method of treating a subject for depression, which comprises administering to the subject a pharmaceutical composition consisting essentially of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof in an amount effective to treat the subject and a carrier.

2. The method of claim 1, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered orally or rectally.

3. The method of claim 2, wherein the amount administered is 2 to 20 mg per daily dosage unit.

4. The method of claim 3, wherein the amount administered is 5 to 10 mg per daily dosage unit.

5. The method of claim 1, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered parenterally.

6. The method of claim 5, wherein the amount administered is 1 to 10 mg per mL per daily dosage unit.

7. The method of claim 6, wherein the amount administered is 2 to 5 mg per mL per daily dosage unit.
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