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|Title:||Ophthalmic compositions comprising emedastine and methods for their use|
|Abstract:||Topical ophthalmic compositions comprising 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts have been found to be useful in treating ocular allergies, especially allergic conjunctivitis, giant papillary conjunctivitis, and vernal conjunctivitis.|
|Inventor(s):||Yanni; John M. (Burleson, TX), Robertson; Stella M. (Arlington, TX), Okumura; Shigetoshi (Nara, JP), Tanaka; Hitoshi (Nara-ken, JP), Saito; Tadayuki (Osaka, JP)|
|Assignee:||Alcon Laboratories, Inc. (Fort Worth, TX)|
|Filing Date:||May 22, 1995|
|Claims:||1. A method for treating the pruritus and/or edema associated with giant papillary conjunctivitis and vernal conjunctivitis, comprising topically administering to an affected eye an antihistaminic effective amount of a compound selected from the group consisting of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts. |
2. The method of claim 1, wherein said compound is present at a concentration between about 0.0001 and about 1.0 wt %.
3. The method of claim 2, wherein said compound is present at a concentration between about 0.005 and about 0.2 wt %.
4. The method of claim 3, wherein said compound is present at a concentration between about 0.05 and about 0.2 wt %.
5. The method of claim 1, wherein the compound comprises the difumarate salt of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole.
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