Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

US Department of Justice
Medtronic
Daiichi Sankyo
Fuji
Dow
US Army
Cipla
Farmers Insurance
McKinsey
Cerilliant

Generated: August 19, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Composition for sustained release of human growth hormone
Abstract:The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
Inventor(s): Johnson; OluFunmi Lily (Cambridge, MA), Ganmukhi; Medha M. (Wexford, PA), Bernstein; Howard (Cambridge, MA), Auer; Henry (Belmont, MA), Khan; M. Amin (Dowington, PA)
Assignee: Alkermes, Inc. (Cambridge, MA)
Filing Date:Jun 07, 1995
Application Number:08/477,725
Claims:1. A method for forming a metal cation-complexed human growth hormone, comprising the steps of:

a) forming a solution containing human growth hormone;

b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and

c) drying said suspension to form the metal cation-complexed human growth hormone.

2. A method of claim 1 wherein the molar ratio of metal cation component to hGH is between about 6:1 to about 10:1.

3. A method of claim 1 wherein the hGH solution is in a sodium bicarbonate buffer.

4. A method for forming a zinc-complexed human growth hormone, comprising the steps of:

a) forming a solution containing human growth hormone;

b) dispersing zinc acetate within the human growth hormone solution under pH conditions suitable for complexing zinc with the human growth hormone, thereby forming a zinc-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and

c) drying said suspension to form the zinc-complexed human growth hormone.

5. A method for forming a metal cation-complexed human growth hormone, comprising the steps of:

a) forming a solution containing human growth hormone;

b) dispersing a multivalent metal cation component within the human growth hormone solution at a pH in the range of between about 7.0 and about 7.4, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and

c) drying said suspension to form the metal cation-complexed human growth hormone.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Accenture
Merck
US Department of Justice
Argus Health
Moodys
Cipla
Colorcon
US Army
Cerilliant
UBS

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot