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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Queensland Health
Julphar
Farmers Insurance
Express Scripts
Johnson and Johnson
Baxter
Dow
QuintilesIMS

Generated: May 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,665,761

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Title: Methods for administration of taxol
Abstract:Taxol dosages of about 135 mg/m.sup.2 or greater are administered via infusions of less than 6 hours duration; the method makes it possible to provide taxol infusions on an out-patient basis to patients who do not otherwise require hospitalization. In a preferred embodiment, about 135 mg/m.sup.2 of taxol in a cremaphor emulsion is infused over a 3 hour duration, following patient pretreatment with steroids, antihistamines, and H.sub.2 -receptor antagonists sufficient to prevent fatal anaphylactic-like reactions, and preferably sufficient to reduce the occurrence of severe anaphylactic-like reactions in greater than 90% of patients treated. In an alternative embodiment, between 135 mg/m.sup.2 and about 175 mg/m.sup.2 of taxol is provided in a 3-hour infusion, following pretreatment to minimize hypersensitivity responses. A method for rechallenging patients with taxol after episodes of acute hypersensitivity reactions is also disclosed, thus enabling patients to continue taxol therapy who would otherwise be deprived of treatment.
Inventor(s): Canetta; Renzo Mauro (Madison, CT), Eisenhauer; Elizabeth (Kingston, CA), Rozencweig; Marcel (Bradford, CT)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:Nov 22, 1996
Application Number:08/755,740
Claims:1. A method for reducing peripheral neurotoxicity symptoms in patients suffering from lung cancer and undergoing taxol therapy comprising reducing peripheral neurotoxicity symptoms in said patients while maintaining an anti-tumor effect by administering about 135 mg/m.sup.2 taxol over a period of about 24 hours.

2. The method of claim 1 wherein the administration of taxol is repeated at least once, about 21 days after the preceding administration.

3. A method for reducing peripheral neurotoxicity symptoms in patients suffering from colon cancer and undergoing taxol therapy comprising reducing peripheral neurotoxicity symptoms in said patients while maintaining an anti-tumor effect by administering about 135 mg/m.sup.2 taxol over a period of about 24 hours.

4. The method of claim 3 wherein the administration of taxol is repeated at least once, about 21 days after the preceding administration.

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Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
Baxter
McKesson
Express Scripts
Federal Trade Commission
Fuji
Colorcon
Cipla
Fish and Richardson

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