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Details for Patent: 5,663,412

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Details for Patent: 5,663,412

Title: Aromatic ketones
Abstract:The present invention relates to substantially pure piperidine derivative compounds of the formulae: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; R.sub.3 is --COOH or --COOR.sub.4 ; R.sub.4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
Inventor(s): D'Ambra; Thomas E. (Wynantskill, NY)
Assignee: Albany Molecular Research, Inc. (Albany, NY)
Filing Date:Aug 08, 1996
Application Number:08/700,556
Claims:1. A substantially pure regioisomer having the formula: ##STR42## wherein X is a halogen;

R.sub.3 is --COOH or --COOR.sub.4 ;

R.sub.4 is an alkyl with 1 to 6 carbon atoms;

A is the substituents of its ring, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, or alkoxy.

2. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen.

3. A substantially pure regioisomer according to claim 1, wherein X is chlorine.

4. A substantially pure regioisomer according to claim 1, wherein X is bromine.

5. A substantially pure regioisomer according to claim 1, wherein X is iodine.

6. A substantially pure regioisomer according to claim 1, wherein R.sub.3 is --COOH.

7. A substantially pure regioisomer according to claim 1, wherein R.sub.3 is --COOR.sub.4.

8. A substantially pure regioisomer according to claim 1, wherein X is chlorine and R.sub.3 is --COOH.

9. A substantially pure regioisomer according to claim 1, wherein X is bromine and R.sub.3 is --COOH.

10. A substantially pure regioisomer according to claim 1, wherein X is iodine and R.sub.3 is --COOH.

11. A substantially pure regioisomer according to claim 1, wherein X is chlorine and R.sub.3 is --COOR.sub.4.

12. A substantially pure regioisomer according to claim 1, wherein X is bromine and R.sub.3 is --COOR.sub.4.

13. A substantially pure regiozsomer according to claim 1, wherein X is iodine and R.sub.3 is --COOR.sub.4.

14. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen and X is chlorine.

15. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen and X is iodine.

16. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen and R.sub.3 is --COOH.

17. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen and R.sub.3 is --COOR.sub.4.

18. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen, X is chlorine, and R.sub.3 is --COOH.

19. A substantially pure regioisomer according to claim 1, wherein each substituent A is a hydrogen, X is chlorine, and R.sub.3 is --COOR.sub.4.
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