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Details for Patent: 5,656,590

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Details for Patent: 5,656,590

Title: Treatment of anorexia and related states
Abstract:Method for treatment of a patient suffering from anorexia or a related condition by administering amylin or an analogue thereof and/or to the patient in an amount sufficient to increase amylin and/or insulin levels in the plasma of the patient.
Inventor(s): Rink; Timothy J. (La Jolla, CA), Young; Andrew A. (San Diego, CA)
Assignee: Amylin Pharmaceuticals, Inc. (San Diego, CA)
Filing Date:Nov 24, 1993
Application Number:08/157,003
Claims:1. A method for treatment of a patient suffering from anorexia comprising the step of:

administering amylin or an analogue thereof to said patient in an amount sufficient to increase the amylin level in the plasma of said patient.

2. A method for treatment of a cachectic patient or a patient undergoing parenteral nutrition comprising the step of:

administering amylin or an analogue thereof to said patient in an amount sufficient to increase the amylin level in the plasma of said patient.

3. The method of claim 1 wherein said amount of amylin or amylin analogue administered is sufficient to increase the anabolic effect of plasma amylin within the liver, and thereby increase glycogen levels by glycogenesis.

4. The method of claim 1 wherein said amylin is administered in an amount sufficient to enhance mobilization of lactate from muscle to form fat in the liver.

5. The method of claim 1 or 2 wherein said amylin or amylin analogue is provided in an amount sufficient to increase adipose tissue in said patient.

6. The method of claim 1 or 2 further comprising administering insulin to said patient an amount sufficient to increase the insulin level in said patient.

7. The method of claim 6 wherein said amylin and/or said insulin are provided in an amount or amounts sufficient to increase adipose tissue in said patient.

8. A method for treating a patient deficient in adipose tissue comprising administering amylin or an amylin analogue alone or in conjunction with insulin in an amount and ratio sufficient to increase adipose tissue in said patient.

9. A method for treatment of a patient suffering from anorexia comprising administering amylin or an analogue thereof to said patient in an amount sufficient to increase the body weight of said patient.

10. A method for treatment of a cachectic patient or a patient undergoing parenteral nutrition comprising administering to said patient an amount of amylin or an amylin analogue sufficient to reduce the amount of weight loss in said patient.

11. The method of claim 9 wherein said amount of amylin or amylin analog administered is sufficient to increase the anabolic effect of plasma amylin within the liver, and thereby increase glycogen levels by glycogenesis.

12. The method of claim 9 wherein said amylin is administered in an amount sufficient to enhance mobilization of lactate from muscle to form fat in the liver.

13. The method of claim 9 or 10 wherein said amylin or amylin analog is provided in an amount sufficient to increase adipose tissue in said patient.

14. The method of claim 9 or 10 further comprising administering to said patient an amount of insulin sufficient to increase the amount of said insulin in said patient.

15. The method of claim 14 wherein said amylin and/or said insulin are provided in an amount or amounts sufficient to increase adipose tissue in said patient.
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