.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,646,113

« Back to Dashboard

Details for Patent: 5,646,113

Title: Treatment of partial growth hormone insensitivity syndrome
Abstract:Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering a dose of greater than 0.3 mg/kg/week of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I alone or in combination with an amount of growth hormone that is effective in combination with IGF-I.
Inventor(s): Attie; Kenneth (San Francisco, CA), Carlsson; Lena Mariana Susann (Gothenburg, SE), Gesundheit; Neil (Los Altos, CA), Goddard; Audrey (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Filing Date:Apr 07, 1994
Application Number:08/224,982
Claims:1. A method for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome comprising administering an effective amount of growth hormone that increases the growth rate of the patient to said patient, whereby said patient has a height less than about -2 standard deviations below normal for age and sex, and has serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels and has a mean or maximum stimulated serum level of growth hormone that is at least normal, wherein the patient does not have Laron syndrome.

2. The method of claim 1 wherein the amount of growth hormone ranges from about 0.35 to 1.0 mg/kg/week.

3. The method of claim 1 wherein the growth hormone is administered once per day.

4. The method of claim 3 wherein the growth hormone is administered by subcutaneous injections.

5. The method of claim 1 wherein the growth hormone is formulated at a pH of 7.4 to 7.8.

6. The method of claim 1 wherein the patient has a heterogeneous GHR gene defect.

7. A method for increasing the growth rate of a human patient with non-GH-deficient short stature but not Laron syndrome comprising detecting whether the patient has a height less than about -2 standard deviations below normal for age and sex, and has serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels and has a mean or maximum stimulated serum level of growth hormone that is at least normal, and, if so, administering an effective amount of growth hormone that increases the growth rate of the patient to said patient.

8. The method of claim 7 wherein the detecting step also determines whether the patient has a heterogeneous GHR gene defect.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc