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Details for Patent: 5,614,557

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Details for Patent: 5,614,557

Title: Method of controlling tumor growth rate
Abstract:.alpha.-Fluoromethyl- or .alpha.-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.
Inventor(s): Bey; Philippe (Strasbourg, FR), Jung; Michel (Graffenstaden, FR)
Assignee: Marion Merrell et Compagnie C/O Merrell Pharmaceuticals Inc. (Cincinnati, OH)
Filing Date:Mar 14, 1995
Application Number:08/403,531
Claims:1. A method of controlling tumor growth susceptible to treatment with the combination below in a patient in need thereof comprising concomitantly administering to said patient an effective anti-tumor amount of methylglyoxal bis(guanylhydrazone) and an effective polyamine biosynthesis inhibitory amount of .alpha.-difluoromethyl ornithine or a pharmaceutically acceptable salt thereof.

2. A process of claim 1 wherein the tumor to be treated is lymphoma.

3. A process of claim 1 wherein the tumor to be treated is Hodgkins Disease.
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