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|Title:||Method of controlling tumor growth rate|
|Abstract:||.alpha.-Fluoromethyl- or .alpha.-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.|
|Inventor(s):||Bey; Philippe (Strasbourg, FR), Jung; Michel (Graffenstaden, FR)|
|Assignee:||Marion Merrell et Compagnie C/O Merrell Pharmaceuticals Inc. (Cincinnati, OH)|
|Filing Date:||Mar 14, 1995|
|Claims:||1. A method of controlling tumor growth susceptible to treatment with the combination below in a patient in need thereof comprising concomitantly administering to said patient an effective anti-tumor amount of methylglyoxal bis(guanylhydrazone) and an effective polyamine biosynthesis inhibitory amount of .alpha.-difluoromethyl ornithine or a pharmaceutically acceptable salt thereof. |
2. A process of claim 1 wherein the tumor to be treated is lymphoma.
3. A process of claim 1 wherein the tumor to be treated is Hodgkins Disease.