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Details for Patent: 5,610,168

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Details for Patent: 5,610,168

Title: Methods of use for inhibiting bone loss and lowering serum cholesterol
Abstract:A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s): Draper; Michael W. (Carmel, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Apr 14, 1995
Application Number:08/422,289
Claims:1. A method of lowering serum cholesterol levels in a human comprising administering to a human in need thereof a compound of the formula ##STR3## or a pharmaceutically acceptable salt or solvate thereof, in an amount of about 50 to about 150 mg/day.

2. A method of claim 1 wherein the human is a female.

3. A method of claim 2 wherein the female is estrogen deficient.

4. A method of claim 3 wherein the female is post-menopausal.

5. A method of claim 1 wherein the compound of formula I is administered in an amount of about 60 to about 150 mg/day.

6. A method of claim 1 wherein the compound of formula I is administered in an amount of 60 mg/day.

7. A method of claim 1 wherein the compound of formula I is administered in an amount of 75 mg/day.

8. A method of claim 1 wherein the compound of formula I is administered in an amount of 100 mg/day.

9. A method of claim 1 wherein the compound of formula I is administered in an amount of 125 mg/day.

10. A method of claim 1 wherein the compound of formula I is administered in an amount of 150 mg/day.

11. A method of claim 1 wherein the compound is the hydrochloride salt.
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