Details for Patent: 5,608,090
✉ Email this page to a colleague
Title: | GABA and L-glutamic acid analogs for antiseizure treatment |
Abstract: | A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed. |
Inventor(s): | Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis M. (Holland, MI), Franklin; Lloyd C. (Hamilton, MI), Schwindt; Mark A. (Holland, MI) |
Assignee: | Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI) |
Filing Date: | Apr 12, 1995 |
Application Number: | 08/420,577 |
Claims: | 1. A compound which is (S)-3-(azidomethyl)-5-methyl-hexanoic acid. 2. A compound which is (S)-3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester. 3. A compound which is 3-(azidomethyl)-5-methyl-hexanoic acid, or 3-(azidomethyl-5-methyl-hexanoic acid, 1,1-dimethylethyl ester. 4. A compound which is 3-(azidomethyl)-5-methyl-hexanoic acid, phenylmethyl ester, 3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester, or 3-(azidomethyl)-5-methyl-hexanoic acid. |