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|Title:||GABA and L-glutamic acid analogs for antiseizure treatment|
|Abstract:||A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.|
|Inventor(s):||Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis M. (Holland, MI), Franklin; Lloyd C. (Hamilton, MI), Schwindt; Mark A. (Holland, MI)|
|Assignee:||Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI)|
|Filing Date:||Apr 12, 1995|
|Claims:||1. A compound which is (S)-3-(azidomethyl)-5-methyl-hexanoic acid. |
2. A compound which is
(S)-3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester.
3. A compound which is
3-(azidomethyl)-5-methyl-hexanoic acid, or
3-(azidomethyl-5-methyl-hexanoic acid, 1,1-dimethylethyl ester.
4. A compound which is
3-(azidomethyl)-5-methyl-hexanoic acid, phenylmethyl ester,
3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester, or
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