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Details for Patent: 5,608,090

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Details for Patent: 5,608,090

Title: GABA and L-glutamic acid analogs for antiseizure treatment
Abstract:A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
Inventor(s): Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis M. (Holland, MI), Franklin; Lloyd C. (Hamilton, MI), Schwindt; Mark A. (Holland, MI)
Assignee: Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI)
Filing Date:Apr 12, 1995
Application Number:08/420,577
Claims:1. A compound which is (S)-3-(azidomethyl)-5-methyl-hexanoic acid.

2. A compound which is

(S)-3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester.

3. A compound which is

3-(azidomethyl)-5-methyl-hexanoic acid, or

3-(azidomethyl-5-methyl-hexanoic acid, 1,1-dimethylethyl ester.

4. A compound which is

3-(azidomethyl)-5-methyl-hexanoic acid, phenylmethyl ester,

3-(azidomethyl)-5-methyl-hexanoic acid, 1,1-dimethylethyl ester, or

3-(azidomethyl)-5-methyl-hexanoic acid.
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