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Details for Patent: 5,601,846

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Details for Patent: 5,601,846

Title: Proteinoid microspheres and methods for preparation and use thereof
Abstract:Improved proteinoid micropheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid microspheres are soluble within selected pH ranges within the gastrointestinal tract and display enhanced stability towards least one of photolysis or decomposition over time. The proteinoid microspheres are prepared from proteinoids having between 2 and 8 amino acids and having a molecular weight of about 1000 daltons.
Inventor(s): Milstein; Sam J. (Brooklyn, NY), Kantor; Martin L. (Mamaroneck, NY)
Assignee: Emisphere Technologies, Inc. (Hawthorne, NY)
Filing Date:May 09, 1995
Application Number:08/437,698
Claims:1. A method for delivering a biologically active agent to a mammal in need of said agent, said method comprising orally administering a composition comprising:

(A) a biologically active agent encapsulated,

(B) within a microsphere carrier, said carrier comprising a proteinoid comprising

(i) at least one monomer selected from the group consisting of tyrosine and phenylalanine;

(ii) at least one monomer selected from the group consisting of glutamic acid, pyroglutamic acid, glutamine, and aspartic acid; and

(iii) optionally at least one monomer selected from the group consisting of lysine, arginine, and ornithine, and

(C) a physiologically compatible excipient said proteinoid being soluble within a selected pH range.

2. A method as defined in claim 1, wherein said proteinoid forms a wall and said biologically active agent is encapsulated within said wall.

3. A method as defined in claim 1, wherein said proteinoid is an acid-soluble proteinoid.

4. A method as defined in claim 3, wherein the monoclonal antibody in murine IgG.

5. A method as defined in claim 1, wherein said proteinoid is a base-soluble proteinoid.

6. A method as defined in claim 1, wherein said biologically active agent is a monoclonal antibody.

7. A method as defined in claim 1, wherein said biologically active agent comprises at least one protein.

8. A method as defined in claim 7, wherein said protein comprises erythropoietin.

9. A method as defined in claim 8, wherein said protein comprises human growth factor.

10. A method as defined in claim 8, wherein said protein comprises bovine growth factor.

11. A method as defined in claim 7, wherein said protein comprises alpha interferon.

12. A method as defined in claim 7, wherein said protein comprises calcitonin.

13. A method as defined in claim 7, wherein said protein comprises insulin.

14. A method as defined in claim 7, wherein said protein comprises atrial natriuretic factor.

15. A method as defined in claim 7, wherein said protein comprises interleukin II.

16. A method as defined in claim 7, wherein said protein comprises M-protein.

17. A method as defined in claim 1, wherein said biologically active agent comprises at least one polysaccharide.

18. A method as defined in claim 7, wherein said polysaccharide comprises heparin.

19. A method as defined in claim 1, wherein said biologically active agent comprises an antigen.

20. A method as defined in claim 1, wherein said biologically active agent comprises aspirin.

21. A method as defined in claim 1, wherein said biologically active agent comprises a quinolone.

22. A method as defined in claim 1, wherein said biologically active agent comprises an antimicrobial agent.
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