.

Deeper Knowledge, Faster

  • Identify first generic entrants
  • Obtain formulation and manufacturing information
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Fish and Richardson
UBS
Cipla
Farmers Insurance
Johnson and Johnson
Daiichi Sankyo
McKinsey
Colorcon
Healthtrust
US Army

Generated: December 15, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biph enyls useful as angiotensin-II antagonists
Abstract:Angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An compound is: 4'-[(2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-ben zimidazol-1-yl)-methyl]-biphenyl-2-carboxylic acid.
Inventor(s): Hauel; Norbert (Schemmerhofen, DE), Narr, deceased; Berthold (late of Biberach, DE), Ries; Uwe (Biberch, DE), van Meel; Jacobus C. A. (Mittelbiberach, DE), Wienen; Wolfgang (Biberach/Rissegg, DE), Entzeroth; Michael (Warthausen, DE)
Assignee: Dr. Karl Thomae GmbH (Biberach an der Riss, DE)
Filing Date:Jun 01, 1995
Application Number:08/456,337
Claims:1. A compound of the formula I ##STR30## wherein R.sub.1 is in the 4-position and represents a C.sub.1-4 -alkyl, C.sub.3-7 -cycloalkyl or trifluoromethyl group,

R.sub.2 represents a 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl group,

R.sub.3 represents a C.sub.1-5 -alkyl group or cyclopropyl, and

R.sub.4 denotes a 1H-tetrazolyl group or an R.sub.a O--CO-- group, wherein

R.sub.a denotes a hydrogen atom or a straight-chained or branched C.sub.1-4 -alkyl group,

or a pharmaceutically acceptable salt thereof.

2. In accordance with claim 1, a compound of the formula I, wherein

R.sub.2 is in the 6-position,

or a pharmaceutically acceptable salt thereof.

3. In accordance with claim 2, a compound of the formula I, wherein

R.sub.1 represents a methyl group,

R.sub.2 is in the 6-position and represents a 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl group,

R.sub.3 represents a C.sub.1-5 -alkyl group, and

R.sub.4 represents a carboxy or 1H-tetrazolyl group,

or a pharmaceutically acceptable salt thereof.

4. 4'-[(2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydro -imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxyl ic acid or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound as in any one of claims 1, 2, 3 or 4.

6. A method for treating hypertension which comprises administering to a mammalian host suffering from the same an antihypertensive amount of a compound as in any one of claims 1, 2, 3 or 4.
« Back to Dashboard

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

Deloitte
UBS
Boehringer Ingelheim
QuintilesIMS
Harvard Business School
Chinese Patent Office
Federal Trade Commission
Teva
US Department of Justice
Colorcon

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

botpot