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Serving 500+ biopharmaceutical companies globally:

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Generated: July 21, 2017

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Details for Patent: 5,583,129

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Details for Patent: 5,583,129

Title: Composition for contraception
Abstract:This invention relates to a method of inducing contraception comprising administering an estrogen selected from 2.0 to 6.0 mg of 17.beta.-estradiol and 0.015 to 0.020 mg of ethinylestradiol; and a gestagen selected from 0.05 to 0.075 mg of gestodene, 0.075 to 0.125 mg of levonorgestrel, 0.06 to 0.15 mg of desogestrel, 0.06 to 0.15 mg of 3-ketodesogestrel, 0.1 to 0.3 mg of drospirenone, 0.1 to 0.2 mg of cyproterone acetate, 0.2 to 0.3 mg of norgestimate and >0.35 to 0.75 mg of norethisterone for a female of reproductive age, who has not yet reached premenopause, by administration for 23 or 24 days, beginning on day one of the menstrual cycle, followed by 5 or 4 pill-free or sugar pill days, during a total of 28 days in the administration cycle.
Inventor(s): Spona; J urgen (A-1190 Vienna, AT), D usterberg; Bernd (D-12307 Berlin, DE), L udicke; Frank (CH-1211 Geneva 4, CH)
Assignee:
Filing Date:Jun 30, 1994
Application Number:08/268,996
Claims:1. A method of inducing contraception in a female of reproductive age who has not yet reached premenopause, comprising administering to said female a composition comprising an estrogen selected from

2.0 to 6.0 mg of 17.beta.-estradiol and

0.015 to 0.020 mg of ethinylestradiol;

and a gestagen selected from

0.05 to 0.075 mg of gestodene,

0.075 to 0.125 mg of levonorgestrel,

0.06 to 0.15 mg of desogestrel,

0.06 to 0.15 mg of 3-ketodesogestrel,

0.1 to 0.3 mg of drospirenone,

0.1 to 0.2 mg of cyproterone acetate,

0.2 to 0.3 mg of norgestimate and

>0.35 to 0.75 mg of norethisterone;

wherein the composition is administered for 23 or 24 days, beginning on day one of the menstrual cycle, followed by 5 or 4 pill-free or sugar pill days, during a total of 28 days in the administration cycle.

2. A method according to claim 1, whereby the estrogen is ethinylestradiol.

3. A method according to claim 1, whereby the estrogen is 17.beta.-estradiol.

4. A method according to claim 1, whereby the gestagen is gestodene.

5. A method according to claim 1, whereby the gestagen is levonorgestrel.

6. A method according to claim 1, whereby the gestagen is cyproterone acetate or drospirenone.

7. A method according to claim 1, whereby the composition comprises an estrogen selected from

>2.0 to 6.0 mg of 17.beta.-estradiol and

0.020 mg of ethinylestradiol;

and a gestagen selected from

>0.06 to 0.075 mg of gestodene,

>0.100 to 0.125 mg of levonorgestrel,

>0.10 to 0.15 mg of desogestrel,

>0.10 to 0.15 mg of 3-ketodesogestrel,

0.25 to 0.30 mg of drospirenone,

0.1 to 0.2 mg of cyproterone acetate,

0.2 to 0.3 mg of norgestimate and

0.50 to 0.75 mg of norethisterone.

8. A method according to claim 1, whereby the estrogen is present in a dose of 20 .mu.g of ethinylestradiol or an equivalent dose of 17.beta.-estradiol and the gestagen is present in a dose of 75 .mu.g of gestodene or an equivalent dose of levonorgestrel, cyproterone acetate or drospirenone.
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Serving 500+ biopharmaceutical companies globally:

Healthtrust
QuintilesIMS
Colorcon
Deloitte
Baxter
McKinsey
Johnson and Johnson
UBS
Moodys
Argus Health

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