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Details for Patent: 5,582,591

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Details for Patent: 5,582,591

Title: Delivery of solid drug compositions
Abstract:A method of parenterally administering a drug to a patient for immediate dispersal of the drug once administered by obtaining an anhydrous, solid drug composition consisting essentially of the drug and up to 50%, by weight, of a pharmaceutically acceptable carrier, wherein the drug and the carrier are selected and compounded such that the drug is dispersed from the composition upon contact with parenteral fluids and is distributed within the patient's bloodstream according to a blood level profile of the drug that is comparable to a blood level profile of the drug when administered in a liquid formulation, and introducing the solid drug composition into parenteral fluids of the patient.
Inventor(s): Cheikh; Roland C. (Issy-Les-Moulineaux, FR)
Assignee: Delab (Paris, FR)
Filing Date:Sep 02, 1994
Application Number:08/300,713
Claims:1. A method of parenterally administering a drug to a patient for immediate dispersal of the drug once administered, said method comprising

obtaining an anhydrous, solid drug composition consisting essentially of said drug and up to 50%, by weight, of a pharmaceutically acceptable carrier, wherein said drug and said carrier are selected and compounded such that said drug is dispersed from said composition upon contact with parenteral fluids and is distributed within the patient's bloodstream according to a blood level profile of said drug that is comparable to a blood level profile of said drug when administered in a liquid formulation, and

introducing said solid drug composition into parenteral fluids of the patient.

2. A method of claim 1, wherein said composition is compounded with a surface area to weight ratio of at least 10 square millimeters per milligram of said drug.

3. A method of claim 2, wherein said solid drug composition is in the form of a cylinder.

4. A method of claim 1, wherein said drug is a peptide, polypeptide, or protein.

5. A method of claim 4, wherein said drug is selected from the group consisting of insulin, luteinizing hormone-releasing hormone (LH-RH), somatostatin, growth hormone releasing factor (GRF), and analogs thereof.

6. A method of claim 1, wherein said drug is selected from the group consisting of cytostatic compounds, analgesic compounds, and hormones.

7. A method of claim 1, wherein said drug is a vaccine.

8. A method of claim 1, wherein said carrier is water-soluble.

9. A method of claim 1, wherein said carrier is a polymer.

10. A method of claim 1, wherein said carrier is a cellulose, hyaluronic acid, polyalcohol, or sugar.

11. A method of claim 1, wherein said composition consists essentially of said drug and no carrier.
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