Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Abstract:||Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.|
|Inventor(s):||Platt; Frances M. (Oxford, GB), Neises; Gabrielle R. (Chesterfield, GB), Dwek; Raymond A. (Oxford, GB), Butters; Terry D. (Oxford, GB)|
|Assignee:||Monsanto Company (St. Louis, MO)|
|Filing Date:||Mar 01, 1995|
|Claims:||1. The method of inhibiting the surface expression of glycolipid receptors for bacteria and bacterial toxins comprising subjecting cells susceptible to said expression to an effective amount for inhibiting said expression of an N-alkyl derivative of deoxygalactonojirimycin in which said alkyl contains from 3-6 carbon atoms. |
2. The method of claim 1 in which the alkyl group contains from 4-6 carbon atoms.
3. The method of claim 2 in which the alkyl group is butyl.
4. The method of claim 2 in which the alkyl group is hexyl.
5. The method of claim 1 in which the inhibitory effective amount is from about 50 .mu.M to about 500 .mu.M.
6. The method of claim 1 in which the bacterial toxin is cholera toxin.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.