.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,580,575

« Back to Dashboard

Details for Patent: 5,580,575

Title: Therapeutic drug delivery systems
Abstract:Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
Inventor(s): Unger; Evan C. (Tucson, AZ), Fritz; Thomas A. (Tucson, AZ), Matsunaga; Terry (Tucson, AZ), Ramaswami; VaradaRajan (Tucson, AZ), Yellowhair; David (Tucson, AZ), Wu; Guanli (Tucson, AZ)
Assignee: ImaRx Pharmaceutical Corp. (Tucson, AZ)
Filing Date:Jun 11, 1993
Application Number:08/076,250
Claims:1. A method for the controlled delivery of therapeutic compounds to a region of a patient comprising:

(i) administering to the patient an aqueous suspension of gas-filled liposomes, said gas-filled liposomes comprising a therapeutic compound, and further comprising at least about 50% gas in the interior thereof;

(ii) monitoring the liposomes using ultrasound to determine the presence of the liposomes in the region; and

(iii) inducing the rupture of the liposomes using ultrasound to release the therapeutic compound in the region to achieve a therapeutic effect.

2. A method of claim 1 wherein the liposomes are administered intravenously.

3. A method of claim 1 wherein the liposomes are comprised of at least one lipid selected from the group consisting of dipalmitoylposphatidylcholine, dipalmitoylphosphatidylethanolamine, and a phosphatidic acid, and said liposomes further comprising polyethylene glycol.

4. A method of claim 1 wherein the liposomes are filled with a gas selected from the group consisting of air, nitrogen, carbon dioxide, oxygen, argon, xenon, helium, and neon.

5. A method of claim 4 wherein the liposomes are filled with nitrogen gas.

6. A method of claim 1 wherein said liposomes are stored suspended in an aqueous medium.

7. A method of claim 1 wherein the liposomes have a reflectivity of between about 2 dB and about 20 dB.

8. A method of claim 1 wherein the liposomes comprise gas-filled liposomes prepared by a vacuum drying gas installation method and having encapsulated therein a therapeutic compound.

9. A method of claim 1 wherein the liposomes comprise gas-filled liposomes prepared by a gel state shaking gas instillation method.

10. A method for the controlled delivery of a drug to an internal bodily region of a patient comprising:

(a) administering to the patient an aqueous suspension of a drug delivery system comprising gas-filled liposomes prepared by a vacuum drying gas instillation method, said liposomes comprising at least about 90% gas in the interior thereof and having encapsulated therein a drug;

(b) monitoring the liposomes using ultrasound to determine the presence of said liposomes in the region; and

(c) inducing the rupture of the liposomes using ultrasound to release the drugs in the region to achieve a therapeutic effect.

11. A method according to claim 10 wherein the drug is delivered in the area of the patient's left heart.

12. The method of claim 1 wherein liposomes are administered via a nebulizer.

13. The method of claim 12 wherein the liposomes are targeted to the lung.

14. The method of claim 13 wherein said therapeutic is antisense ras/p53.

15. The method of claim 1 wherein the liposomes are comprised of at least one dipalmitoyl lipid.

16. The method of claim 1 wherein said therapeutic compound is selected from the group consisting of carbohydrates, peptides, glycopeptides, glycolipids and lectins, said therapeutic compound incorporated into the surface of said liposomes.

17. The method of claim 1 wherein the liposomes comprise at least about 90% gas in the interior thereof.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc