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Details for Patent: 5,578,323

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Details for Patent: 5,578,323

Title: Proteinoid carriers and methods for preparation and use thereof
Abstract:Improved proteinoid carriers and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid carriers are soluble within selected pH ranges within the gastrointestinal tract and display enhanced stability towards at least one of photolysis or decomposition over time. The proteinoid carriers are prepared from proteinoids having between 2 and 20 amino acids and having a molecular weight of between about 250 and 2400 daltons.
Inventor(s): Milstein; Sam J. (Larchmont, NY), Kantor; Martin L. (Mamaroneck, NY)
Assignee: Emisphere Technologies, Inc. (Hawthorne, NY)
Filing Date:Jun 14, 1993
Application Number:08/076,803
Claims:1. A proteinoid comprising:

(i) at least one monomer selected from the group consisting of tyrosine and phenylalanine,

(ii) at least one monomer selected from the group consisting of glutamic acid, pyroglutamic acid, glutamine, and aspartic acid; and

(iii) optionally at least one monomer selected from the group consisting of lysine, arginine, and ornithine,

said proteinoid being a microsphere or microcapsule-forming proteinoid and being soluble within a selected pH range.

2. The proteinoid of claim 1, having a molecular weight of ranging from about 250 to about 2400.

3. The proteinoid of claim 2, having a molecular weight ranging from about 250 to about 400.

4. The proteinoid of claim 1, wherein said proteinoid comprises from 2 to 20 amino acids.

5. The proteinoid of claim 4, wherein said proteinoid comprises from 2 to 8 amino acids.

6. The proteinoid of claim 1, wherein said proteinoid is acid-soluble.

7. The proteinoid of claim 1, wherein said proteinoid is base-soluble.
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