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Details for Patent: 5,574,035

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Details for Patent: 5,574,035

Title: S-timolol hemihydrate composition and method of preparation therefor
Abstract:A novel compound and method for making and using compositions containing S--(--)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5 thiadiazole hemihydrate useful for administration to a subject particularly for topical administration as a pharmaceutical agent for treating known conditions and disorder.
Inventor(s): Per alampi; Markku (SF-36200 Kangasala, FI)
Filing Date:Oct 07, 1994
Application Number:08/319,868
Claims:1. A pharmaceutical composition for the topical application to the eye of a subject comprising S--(--) -3-morpholino-4-(3-tert-butyl-amino-2-hydroxypropoxy)-1,2,5-thiadiazole hemihydrate.

2. The composition of claim 1 wherein the composition is in a dosage form.

3. Process for making a composition for topical treatment of a subject comprising the steps of:

crystallizing S--(--)-3-morpholino-4-(3-tert-butyl-amino-2-hydroxypropoxy)-1,2,5-thiadia zole hemihydrate from an aqueous solution containing S-timolol base and at least one organic solvent;

selecting one or more pharmaceutically acceptable adjuvants for topical administration to the subject; and

admixing the selected adjuvants with the S--(--)-3-morpholino 4-(3-tert-butyl-amino-2-hydroxypropoxy)- 1,2,5-thiadiazole hemihydrate.

4. The process of claim 1 further comprising dissolving the S--(--)-3-morpholino-4-(3-tert-butyl-amino-2-hydroxypropoxy)-1,2,5-thiad iazole hemihydrate and selected adjuvants in aqueous solution.

5. The process of claim 1 further comprising forming the composition into a dosage form.

6. The process of claim 4 further comprising forming the composition into a dosage form.
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