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Details for Patent: 5,558,854

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Details for Patent: 5,558,854

Title: Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas
Abstract:Ultrasound contrast media comprising gaseous perfluoropentane and gaseous perfluorohexane are disclosed.
Inventor(s): Quay; Steven C. (Pacific Palisades, CA)
Assignee: Sonus Pharmaceuticals (Bothwell, WA)
Filing Date:Jan 30, 1995
Application Number:08/380,085
Claims:1. Contrast media for ultrasound imaging comprising gaseous dodecafluoropentane.

2. The contrast media of claim 1 wherein a portion of said dodecafluoropentane is present as microbubbles suspended in a carrier.

3. The contrast media of claim 2 wherein said carrier is an aqueous liquid.

4. The contrast media of claim 3 wherein a portion of said microbubbles are less than 8 microns in diameter.

5. A biocompatible ultrasound contrast agent containing gas-filled liposomes, the improvement comprising including dodecafluoropentane in said gas.

6. A biocompatible ultrasound contrast agent containing a suspension of encapsulated air-filled microspheres, the improvement comprising replacing all or a portion of the air with dodecafluoropentane.

7. A biocompatible ultrasound contrast agent containing a suspension of crystals in a saccharide diluent, the improvement comprising providing gaseous dodecafluoropentane in said diluent.

8. A biocompatible ultrasound contrast agent containing an emulsion of highly fluorinated organic compounds, the improvement comprising providing gaseous dodecafluoropentane in said emulsion.

9. A biocompatible ultrasound contrast agent containing an air-filled microbubble suspension, the improvement comprising providing dodecafluoropentane gas within the microbubbles of said suspension.

10. Contrast media for ultrasound imaging comprising gaseous perfluorohexane.

11. The contrast agent of claim 10 wherein a portion of said perfluorohexane is present as microbubbles suspended in a carrier.

12. The contrast agent of claim 11 wherein said carrier is an aqueous liquid.

13. The contrast agent of claim 11 wherein a portion of said microbubbles are less than 8 microns in diameter.
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