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Generated: January 17, 2018

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Title: Compositions for treatment of glaucoma
Abstract:Compositions for controlling glaucoma and ocular hypertension are disclosed.
Inventor(s): Ali; Yusuf (Forth Worth, TX), Jani; Rajni (Forth Worth, TX), McCarty; George R. (Forth Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Filing Date:Nov 04, 1994
Application Number:08/334,512
Claims:1. A topical ophthalmic composition for controlling glaucoma and/or ocular hypertension comprising 0.1 to 1.0 wt./vol. % betaxolol, 0.25 to 10.0 wt./vol. % pilocarpine, 0.05 to 10.0 wt./vol. % poly(styrene-divinyl benzene) sulfonic acid, and 0.01 to 5.0 wt./vol. % polyanionic polymer selected from the group consisting of Carbomer 934P and Carbomer 974P.

2. The composition of claim 1 wherein the polyanionic polymer is Carbomer 934P.

3. The composition of claim 2 wherein the betaxolol concentration is 0.25%, the pilocarpine concentration is 1.75%, the resin concentration is 0.25%, and the Carbomer 934P concentration is 0.40%.

4. The composition of claim 1 wherein the polyanionic polymer is Carbomer 974P.

5. The composition of claim 4 wherein the betaxolol concentration is 0.25%, the pilocarpine concentration is 1.75%, the resin concentration is 0.25%, and the Carbomer 974P concentration is 0.40%.

6. A method for controlling intraocular pressure by topically applying to the eye a composition which comprises 0.1 to 1.0 wt./vol. % betatolol, 0.25 to 10.0 wt./vol. % pilocarpine, 0.05 to 10.0 wt./vol. % poly(styrene-divinyl benzene) sulfonic acid, and 0.01 to 5.0 wt./vol. % polyanionic polymer selected from the group consisting of Carbomer 934P and Carbomer 974P.

7. The method of claim 6 wherein the polyanionic polymer is Carbomer 934P.

8. The method of claim 7 wherein the betaxolol concentration is 0.25%, the pilocarpine concentration is 1.75%, the resin concentration is 0.25%, and the Carbomer 934P concentration is 0.40%.

9. The method of claim 6 wherein the polyanionic polymer is Carbomer 974P.

10. The method of claim 9 wherein the betaxolol concentration is 0.25%, the pilocarpine concentration is 1.75%, the resin concentration is 0.25%, and the Carbomer 974P concentration is 0.40%.
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