.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,552,160

« Back to Dashboard

Details for Patent: 5,552,160

Title: Surface modified NSAID nanoparticles
Abstract:Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric irritation following oral administration and/or hastened onset of action.
Inventor(s): Liversidge; Gary G. (West Chester, PA), Conzentino, Jr.; Philip (West Chester, PA), Cundy; Kenneth C. (Pottstown, PA), Sarpotdar; Pramod P. (Malvern, PA)
Assignee: NanoSystems L.L.C. (Collegeville, PA)
Filing Date:Mar 13, 1995
Application Number:08/402,662
Claims:1. Particles consisting essentially of 99.9-10% by weight of crystalline NSAID having a solubility in water of less than 10 mg/ml, said NSAID having a non-crosslinked surface modifier adsorbed on the surface thereof in an amount of 0.1-90% by weight and sufficient to maintain an average particle size of less than about 400 nm.

2. The particles of claim 1 having an effective average particle size of less than 300 nm.

3. The particles of claim 1 wherein said surface modifier is present in an amount of 0.5 to 80% by weight based on the total weight of the dry particle.

4. The particles of claim 1 wherein said NSAID is selected from nabumetone, tiaramide, proquazone, bufexamac, flumizole, epirazole, tinoridine, timegadine, dapsone, aspirin, diflunisal, benorylate, fosfosal, diclofenac, alclofenac, fenclofenac, etodolac, indomethacin, sulindac, tolmetin, fentiazac, tilomisole, carprofen, fenbufen, flurbiprofen, ketoprofen, oxaprozin, suprofen, tiaprofenic acid, ibuprofen, naproxen, fenoprofen, indoprofen, pirprofen, flufenamic, mefenamic, meclofenamic, niflumic, oxyphenbutazone, phenylbutazone, apazone and feprazone, piroxicam, sudoxicam, isoxicam and tenoxicam.

5. The particles of claim 1 wherein said NSAID is selected from naproxen, indomethacin and ibuprofen.

6. The particles of claim 1 wherein said surface modifier is selected from polyvinylpyrrolidone and a block copolymer of ethylene oxide and propylene oxide.

7. Particles according to claim 1 consisting of naproxen having a block copolymer of ethylene oxide and propylene oxide adsorbed on the surface thereof in an amount sufficient to maintain an average particle size of less than about 400 nm.

8. Particles according to claim 1 consisting essentially of naproxen having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an average particle size of less than about 400 nm.

9. A pharmaceutical composition comprising the particles of claim 1 and a pharmaceutically acceptable carrier.

10. A method of treating a mammal comprising administering to the mammal an effective amount of the pharmaceutical composition of claim 9.

11. A method of reducing gastric irritation following oral administration to a mammal of a pharmaceutical composition comprising an NSAID, said method comprising administering the pharmaceutical composition of claim 9.

12. A method of hastening onset of action following administration to a mammal of a pharmaceutical composition an NSAID, said method comprising administering the pharmaceutical composition of claim 9.

13. A method of hastening onset of action following administration to a mammal of pharmaceutical composition, said method comprising administering said pharmaceutical composition in the form of particles consisting essentially of 99.9-10% by weight of a crystalline drug substance having a solubility in water of less than 10 mg/ml, said drug substance having a non-crosslinked surface modifier adsorbed on the surface thereof in an amount of 0.1-90% by weight and sufficient to maintain an average particle size of less than about 400 nm.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc