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Details for Patent: 5,541,155

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Details for Patent: 5,541,155

Title: Acids and acid salts and their use in delivery systems
Abstract:The present invention relates to a delivery system, and in particular to carboxylic acids for use as a delivery system of sensitive agents such as bioactive peptides. The carboxylic acids and salts can form non-covalent mixtures with biologically-active agents. These mixtures are suitable for oral administration of biologically active agents to animals.
Inventor(s): Leone-Bay; Andrea (Ridgefield, CT), Santiago; Noemi (Hawthorne, NY)
Assignee: Emisphere Technologies, Inc. (Hawthorne, NY)
Filing Date:Apr 22, 1994
Application Number:08/231,623
Claims:1. A composition comprising; a compound having the formula: ##STR1## a biologically-active agent selected from the group consisting of a peptide, a mucopolysaccharide, a carbohydrate, a lipid, a pesticide, cromolyn sodium, desferrioxamine (DFO), and a combination of the foregoing.

2. The composition according to claim 1, wherein said biologically-active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, desferrioxamine (DFO), and any combination thereof.

3. The composition according to claim 2, wherein said biologically-active agent comprises an interferon, interleukin-II, insulin, heparin, calcitonin, oxytocin, vasopressin, cromolyn sodium, vancomycin, DFO or any combination thereof.

4. The composition according to claim 3, wherein said biologically-active agent is calcitonin.

5. The composition according to claim 3, wherein said biologically-active agent is heparin.

6. A composition for oral administration to an animal comprising 25 mg of heparin per kg of animal and 300 mg of cyclohexanecarboxylic acid per kg of animal.

7. A composition for oral administration to an animal comprising heparin and cyclohexanecarboxylic acid.
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