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Serving 500+ biopharmaceutical companies globally:

Farmers Insurance
Fish and Richardson
US Army
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Generated: June 26, 2017

DrugPatentWatch Database Preview

Details for Patent: 5,534,527

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Details for Patent: 5,534,527

Title: Methods for inhibiting bone loss by treating with aroylbenzothiophenes and estrogen
Abstract:The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus serve as an effective and acceptable treatment for osteoporosis.
Inventor(s): Black; Larry J. (Indianapolis, IN), Cullinan; George J. (Trafalgar, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Apr 14, 1995
Application Number:08/422,096
Claims:1. A pharmaceutical formulation comprising an effective amount of a compound of formula I ##STR11## wherein X is a bond, CH.sub.2, or CH.sub.2 CH.sub.2 ;

R and R.sup.1, independently, are hydrogen, hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -acyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.2 -C.sub.6 -acyloxy, R.sup.3 -substituted aryloxy, R.sup.3 -substituted aroyloxy, R.sup.4 -substituted carbonyloxy, chloro, or bromo;

R.sup.2 is a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, or hexamethyleneimino;

R.sup.3 is C.sub.1 -C.sub.3 -alkyl, C.sub.1-C.sub.3 -alkoxy, hydrogen, or halo; and

R.sup.4 is C.sub.1 -C.sub.6 -alkoxy or aryloxy; or

a pharmaceutically acceptable salt thereof; estrogen and

a pharmaceutically acceptable carrier.
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Serving 500+ biopharmaceutical companies globally:

Farmers Insurance
Federal Trade Commission
Chinese Patent Office
Fish and Richardson
Express Scripts

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