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Generated: May 20, 2018

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Details for Patent: 5,534,250

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Title: Polymers containing diester units
Abstract:The present invention relates to biodegradable polymers containing diester units of formula (I) where R.sup.1 and R.sup.2 each represents a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group.
Inventor(s): Klaveness; Jo (Oslo, NO), Strande; Per (Oslo, NO), Wiggen; Unni N. (Rasta, NO)
Assignee: Nycomed Imaging AS (Oslo, NO)
Filing Date:May 05, 1993
Application Number:07/982,746
Claims:1. Biodegradable polymers comprising diester units of the formula (I)

where R.sup.1 and R.sup.2 each represents a hydrogen atom or a carbon-attached monovalent organic group or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group.

2. Biodegradable polymers as claimed in claim 1 in which the diester units have the formula (II)

where m and n, which may be the same or different, are 0 or 1.

3. Biodegradable polymers as claimed in claim 2 in which the diester units have the formula (III)

where R.sup.3 is a carbon-attached divalent organic grouping.

4. Biodegradable polymers as claimed in claim 2 wherein n is 0 and m is 0 or 1.

5. Biodegradable polymers as claimed in claim 1 in which R.sup.1 and R.sup.2 are each hydrogen or a carbon-attached hydrocarbyl or heterocyclic group.

6. Biodegradable polymers as claimed in claim 5 in which R.sup.1 and R.sup.2 are each hydrogen or an aliphatic group having up to 10 carbon atoms, a cycloalkyl group having up to 10 carbon atoms, an araliphatic group having up to 20 carbon atoms, an aryl group having up to 20 carbon atoms or a heterocyclic group having up to 20 carbon atoms and one or more heteroatoms selected from the group consisting of O, S and N.

7. Biodegradable polymers as claimed in claim 1 which are block or graft copolymers.

8. Biodegradable polymers as claimed in claim 1 in the form of surgical implants, soft tissue prostheses, sponges, films, wound dressings, flexible sheets, containers and delayed release formulations for drugs and agricultural chemicals, particulate imaging agents or plasticisers.

9. Biodegradable polymers as claimed in claim 1 comprising a plurality of polymer chains cross-linked by diester units of formula (I).

10. Biodegradable polymers as claimed in claim 3 wherein n is 0 and m is 0 or 1.

11. Biodegradable polymers as claimed in claim 3 wherein R.sup.1 and R.sup.2 are each hydrogen or a carbon-attached hydrocarbyl or heterocyclic group.

12. Biodegradable polymers as claimed in claim 3 in which R.sup.3 is selected from the group consisting of alkylene and alkenylene groups having up to 20 carbon atoms, cycloalkylene groups having up to 10 carbon atoms, aralkylene groups having up to 20 carbon atoms, arylene groups having up to 20 carbon atoms, heterocyclic groups having up to 20 carbon atoms and one or more heteroatoms selected from the group consisting of O, S and N, and any of the preceding groups interrupted by oxygen, substituted by oxygen or interrupted and substituted by oxygen.

13. Biodegradable polymers as claimed in claim 1 which are linear polymers.

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Serving hundreds of leading biopharmaceutical companies globally:

AstraZeneca
Merck
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Chubb
US Army
Deloitte
Harvard Business School
Daiichi Sankyo
Teva

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