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Details for Patent: 5,531,982

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Details for Patent: 5,531,982

Title: Antimicrobial oral composition
Abstract:A oral composition which inhibits plaque formation and reduces gingivitis and caries comprising a substantially water insoluble noncationic antimicrobial agent, such as triclosan and an acid reducing agent, such as xylitol. The composition is a dentifrice containing a siliceous polishing agent.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (Cranbury, NJ), Afflitto; John (Brookside, NJ)
Assignee: Colgate Palmolive Company (New York, NY)
Filing Date:Jul 14, 1994
Application Number:08/275,469
Claims:1. An antimicrobial oral composition which has anticaries effectiveness in reducing caries incidence in dentinal fissures even without a fluoride ion source essentially comprising an aqueous humectant vehicle, and when said oral composition is a dentifrice, about 10-30% by weight of a water-insoluble dentally acceptable siliceous polishing agent, said oral composition comprising an effective antiplaque active ingredient amount of a substantially water insoluble noncationic antimicrobial agent, an antibacterial-enhancing agent in amount of about 0.05-4% by weight and at least about 0.1% by weight of xylitol, said oral composition containing at least one of a surface active agent and a flavor oil to facilitate dispersion of said antibacterial agent in said composition.

2. The oral composition claimed in claim 1 wherein said antimicrobial agent is present in amount of about 0.01-5% by weight.

3. The oral composition claimed in claim 1 wherein xylitol is present in amount of about 0.1-5% by weight.

4. The oral composition claimed in claim 1 wherein xylitol is present is amount of about 3-25% by weight.

5. The oral composition claimed in claim 4 wherein xylitol is present in amount of about 5-20% by weight.

6. The oral composition claimed in claim 1 wherein xylitol is present in amount of about 20-40% by weight.

7. The oral composition claimed in claim 1 wherein said antibacterial-enhancing agent is a polycarboxylate.

8. The oral composition claimed in claim 1 wherein said oral composition additionally comprises about 0.5-5% by weight of an organic surface-active agent.

9. The oral composition claimed in claim 1 wherein said oral composition comprises about 0.1-5% by weight of a flavoring oil.

10. The oral composition claimed in claim 1 wherein said oral composition is a dentifrice comprising a dentally acceptable siliceous polishing agent.

11. The oral composition claimed in claim 1 wherein said oral composition is a mouthrinse and said mouthrinse comprises a non-toxic alcohol.

12. The oral composition claimed in claim 1 wherein said oral composition is a dental gel.

13. A method of inhibiting plaque formation comprising applying the oral composition claimed in claim 1 to dental enamel.

14. The oral composition claimed in claim 1 wherein said antibacterial agent is selected from the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benzoic acids, halogenated carbanilides and phenolic compounds.

15. The oral composition claimed in claim 14 wherein said antibacterial agent is a halogenated diphenyl ether.

16. The oral composition claimed in claim 15 wherein said antimicrobial agent is triclosan.

17. The oral composition claimed in claim 16 wherein said amount of said antimicrobial agent is about 0.3-0.5% by weight.

18. The oral composition claimed in claim 7 wherein said polycarboxylate is a 1:4 to 4:1 copolymer of maleic anhydride or acid with methyl vinyl ether.

19. The oral composition claimed in claim 18 wherein said copolymer has a molecular weight of about 30,000 to about 1,000,000.
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