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Details for Patent: 5,529,787

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Details for Patent: 5,529,787

Title: Hydromorphone therapy
Abstract:A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
Inventor(s): Merrill; Sonya (San Jose, CA), Ayer; Atul D. (Palo Alto, CA), Chadha; Navjot (Sunnyvale, CA), Kuczynski; Anthony L. (Mt. View, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Jul 07, 1994
Application Number:08/271,593
Claims:1. A therapeutic composition for the relief of pain comprising 1 to 1000 mg of hydromorphone, 25 to 500 mg of a carboxymethylcellulose possessing a 10,000 to 300,000 molecular weight, 1 to 50 mg of a poly(vinylpyrrolidone) having a 10,000 to 300,000 molecular weight and 0 to 7.5 mg of a lubricant, which therapeutic composition is encased with a semipermeable wall with a passageway through the semipermeable composition.

2. A bilayer comprising a hydromorphone composition that comprises 1 to 1000 mg of hydromorphone. 25 to 500 mg of a carboxymethylcellulose possessing a 10,000 to 300,000 molecular weight, 1 to 50 mg of a poly (vinylpyrrolidone) having, a 10,000 to 300,000 molecular weight, and 0 to 7.5 mg of a lubricant; and an push composition comprising 15 to 250 mg of a poly(alkylene oxide) of 3,000,000 to 7,500,000 molecular weight, 0 to 75 mg of an osmagent, 1 to 50 mg of a hydroxyalkylcellulose, 0 to 10 mg of a tableting lubricant, 0 to 10 mg of an antioxidant, and 0 to 10 mg of a colorant.

3. A method for administering hydromorphone, to a patient in need of pain relief which method comprises admitting orally into the patient a composition comprising 1 to 1000 mg of hydromorphone, 25 to 500 mg of a poly(alkylene oxide) possessing a 150,000 to 500,000 molecular weight, 1 to 50 mg of poly(vinyl pyrrolidone) possessing a 10,000 to 300,000 molecular weight, and 0 to 7.5 mg of a lubricant, an push composition comprising a carboxymethylcellulose having a 450,000 to 2,500,000 molecular weight, and wherein the method administers the hydromorphone at a sustained rate over time for the relief of pain.

4. The method for administering the hydromorphone according to claim 3, wherein the hydromorphone composition and the push composition are surrounded by a semipermeable wall permeable to aqueous biological fluid. and impermeable to the passage of hydromorphone, with a passageway in the semipermeable wall, the poly(alkylene) is replaced by carboxymethylcellulose possessing a 10,000 to 300,000 molecular weight for administering the hydromorphone to the patient for the relief of pain.
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