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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Fuji
McKinsey
Cerilliant
Cipla
Healthtrust
Merck
Teva
QuintilesIMS

Generated: June 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,527,799

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Title: HIV protease inhibitors useful for the treatment of AIDS
Abstract:Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Inventor(s): Vacca; Joseph P. (Telford, PA), Dorsey; Bruce D. (Harleysville, PA), Guare; James P. (Quakertown, PA), Holloway; M. Katharine (Lansdale, PA), Hungate; Randall W. (Lansdale, PA), Levin; Rhonda B. (Lafayette Hill, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Mar 21, 1995
Application Number:08/407,740
Claims:1. A composition, comprising a compound of the structure ##STR316## [Compound J,]3-([4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino)-5-ethyl-6-methylpyri din-2(1H)-one, and, optionally, AZT, or a pharmaceutically acceptable salt of any of the above.

2. A composition, comprising a compound of the structure ##STR317## [Compound J] and AZT, or a pharmaceutically acceptable salt of any of the above.

3. A method of treating AIDS or HIV infection, comprising administering the pharmaceutical composition of claim 1 or 2.

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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
AstraZeneca
Merck
Farmers Insurance
Julphar
Colorcon
Express Scripts
Johnson and Johnson
Healthtrust

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