|Title:||Solid-tumor treatment method|
|Abstract:||A method of administering an anti-tumor compound to a subject is disclosed. The method includes administering to a subject liposomes having sizes predominantly in the range 0.05 to 0.12 microns, and containing an anti-tumor compound in liposome-entrapped form, a surface coating of polyethylene glycol chains, at a surface concentration thereof sufficient to extend the blood circulation time of the liposomes severalfold over that of liposomes in the absence of such coating, and surface-attached antibody molecules effective to bind specifically to tumor-associated antigens present at the tumor site. One liposome composition includes doxorubicin in entrapped form, and, on the liposome surface, a monoclonal antibody against highly proliferating cells in a lung squamous cell carcinoma.|
|Inventor(s):||Allen; Theresa M. (Edmonton, CA), Martin; Francis J. (San Francisco, CA)|
|Assignee:||Sequus Pharmaceuticals, Inc. (Menlo Park, CA)|
|Filing Date:||Mar 31, 1993|
|Claims:||1. A method of administering an anti-tumor compound to a subject, for solid tumor treatment, comprising |
administering to the subject, by parenteral injection, liposomes having sizes in the range of 0.05 to 0.12 microns, and containing an anti-tumor compound in liposome-entrapped form, a surface coating of polyethylene glycol chains at a surface concentration thereof sufficient to extend the blood circulation time of the liposomes severalfold over that of liposomes in the absence of such coating, and antibodies or antibody fragments effective to bind specifically to tumor-associated antigens,
wherein the polyethylene glycol chains contain, in a portion thereof, functionalized reactive groups at their free ends to which said antibodies or antibody fragments are covalently attached.
2. The method of claim 1, wherein said tumor cells are squamous carcinoma cells localized in the lung.
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