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Details for Patent: 5,521,222

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Details for Patent: 5,521,222

Title: Topical ophthalmic pharmaceutical vehicles
Abstract:Ophthalmic pharmaceutical vehicles which become viscous on contacting the eye are disclosed. Ophthalmic compositions of the vehicle and a pharmaceutically active drug are also disclosed.
Inventor(s): Ali; Yusuf (Fort Worth, TX), Reed; Kenneth W. (Lawrenceville, GA)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Filing Date:Dec 14, 1994
Application Number:08/356,044
Claims:1. A topical ophthalmic vehicle comprising: a water soluble carboxy vinyl polymer and calcium ions at concentrations such that the vehicle is administrable as a drop and gels upon instillation as a result of the migration Of calcium ions out of the vehicle.

2. The vehicle of claim 1 wherein the polymer concentration is between about 0.2 and about 10 wt. %.

3. The vehicle of claim 1 wherein the calcium ion concentration is between about 0.01 and 1.0 wt. %.

4. A topical ophthalmic composition comprising: a vehicle comprising a water soluble carboxy vinyl polymer, calcium ions, and a pharmaceutically active drug, the polymer and calcium ions present at concentrations such that the composition is administrable as a drop and gels upon instillation as a result of the migration of calcium ions out of the vehicle.

5. The composition of claim 4 wherein the polymer concentration is between about 0.2 and 10.0 wt. %.

6. The composition of claim 4 wherein the calcium ion concentration is between about 0.01 and 1.0 weight percent.

7. The composition of claim 4 wherein the pharmaceutically active drug is betaxolol.

8. A method of delivering a drug to the eye, which comprises: topically administering a composition comprising a water soluble carboxy vinyl polymer and calcium ions at concentrations such that the composition is administratable as a drop and gels upon instillation as a result of the migration of calcium ions out of the composition.
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