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Details for Patent: 5,521,207

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Details for Patent: 5,521,207

Title: Substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
Abstract:A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##
Inventor(s): Graneto; Matthew J. (St. Louis, MO)
Assignee: G.D. Searle & Co. (Skokie, IL)
Filing Date:Apr 06, 1994
Application Number:08/223,629
Claims:1. Compound which is 4-[5-(3-fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide, or a pharmaceutically-acceptable salt thereof.

2. Pharmaceutical composition comprising a pharmaceutically-acceptable carrier or diluent and a therapeutically-effective amount of 4-[5-(3-fluoro-4-methoxylphenyl)-3(difluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide, or a pharmaceutically-acceptable salt thereof.

3. Method of treating inflammation or an inflammation-associated disorder, said method comprising administering to a subject having said inflammation or said inflammation-associated disorder, a therapeutically-effective amount of 4-[5-(3-fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide, or a pharmaceutically-acceptable salt thereof.

4. The method of claim 3 for use in treatment of inflammation.

5. The method of claim 3 for use in treatment of an inflammation-associated disorder.

6. The method of claim 5 wherein the inflammation-associated disorder is arthritis.

7. The method of claim 5 wherein the inflammation-associated disorder is pain.

8. The method of claim 5 wherein the inflammation-associated disorder is fever.
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