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Details for Patent: 5,521,201

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Details for Patent: 5,521,201

Title: Method for treatment of atherosclerosis
Abstract:A method is provided for the treatment and/or prophylaxis of cardiovascular diseases in a human or non-human mammal, which comprises administering to a human or non-human mammal in need thereof, an effective, non-toxic amount of a compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharmaceuticlaly acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof, in which A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group; R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; R.sup.2 and R.sup.3 each represent hydrogen, or R.sup.2 and R.sup.3 together represent a bond; A.sup.2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6.
Inventor(s): Hindley; Richard M. (Epsom, GB2), Cawthorne; Michael A. (Epsom, GB2)
Assignee: Beecham Group p.l.c. (Brentford) N/A)
Filing Date:Jun 01, 1995
Application Number:08/457,387
Claims:1. A method for the treatment and/or prophylaxis of atherosclerosis in a human or a non-human mammal which comprises administering to said human or non-human mammal an effective non-toxic amount of the following compound:

5-(4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl)-2,4-thiazolidinedione, or a tautomeric form thereof, and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof.
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