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Details for Patent: 5,503,978

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Details for Patent: 5,503,978

Title: Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
Abstract:Methods are described for the identification and preparation of DNA ligands to the HIV-1 reverse transcriptase protein. The invention encompasses specific ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method including ssDNA ligands that inhibit the activity of HIV-1 reverse transcriptase.
Inventor(s): Schneider; Daniel J. (Boulder, CO), Gold; Larry (Boulder, CO), Feigon; Juli (Los Angeles, CA)
Assignee: University Research Corporation (Boulder, CO)
Filing Date:May 06, 1994
Application Number:08/238,863
Claims:1. A method of identifying nucleic acid ligands to HIV-1 reverse transcriptase, comprising:

a) preparing a candidate mixture of deoxyribonucleic acids (DNA);

b) contacting the candidate mixture of DNA with HIV-1 reverse transcriptase, wherein nucleic acids having an increased affinity to HIV-1 reverse transcriptase relative to the candidate mixture may be partitioned from the remainder of the candidate mixture;

c) partitioning the increased affinity nucleic acids from the remainder of the candidate mixture; and

d) amplifying the increased affinity nucleic acids to yield a ligand-enriched mixture of nucleic acids, whereby nucleic acid ligands to HIV-1 reverse transcriptase may be identified.

2. The method of claim 1 further comprising:

(e) repeating steps b), c) and d).

3. The method of claim 1 wherein said candidate mixture of DNA is comprised of single stranded DNA.
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