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|Title:||Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases|
|Abstract:||A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.|
|Inventor(s):||Iwamoto; Toshiro (Tsukuba, JP), Fujie; Akihiko (Tsuchiura, JP), Nitta; Kumiko (Tsuchiura, JP), Tsurumi; Yasuhisa (Tsukuba, JP), Shigematsu; Nobuharu (Tsukuba, JP), Kasahara; Chiyoshi (Ikeda, JP), Hino; Motohiro (Tsuchiura, JP), Okuhara; Masakuni (Tsukuba, JP)|
|Assignee:||Fujisawa Pharmaceutical Co., Ltd. (Osaka, JP)|
|Filing Date:||Mar 28, 1994|
|Claims:||1. A compound of the following general formula (SEQ ID NO: 1): ##STR8## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a pharmaceutically acceptable salt thereof. |
2. A polypeptide compound of claim 1, wherein R.sup.1 and R.sup.2 are each hydroxy, and R.sup.3 is hydroxysulfonyloxy.
3. A pharmaceutical composition which comprises, as an active ingredient, a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.
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