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|Title:||Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs|
|Abstract:||The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.|
|Inventor(s):||Becker; Reinhard (Wiesbaden, DE), Henning: Rainer (Hattersheim am Main, DE), Ruger; Wolfgang (Kelkheim, DE), Teetz; Volker (Hofheim am Taunus, DE), Urbach; Hansjorg (Kronberg/Taunus, DE)|
|Assignee:||Hoechst Aktiengesellschaft (Frankfurt am Main, DE)|
|Filing Date:||Apr 11, 1994|
|Claims:||1. A pharmaceutical composition, comprising a) 1-[N-(1-S-1-[N-(1-S-ethoxycarbonyl-3-phenylpropyl)-S-alanyl]-(2S,3aR,7aS)- octahydro[1H]indole-2-S-carboxylic acid (trandolapril) or a physiologically acceptable salt thereof in combination with b) 4-(2,3-dichlorophenyl)-2,6-dimethyl-3-methoxycarbonyl-5-ethoxycarbonyl-1,4 -dihydropyridine (felodine) or a physiologically acceptable salt thereof, wherein a) and b) are present in a combined amount more effective to lower blood pressure than the individual amounts of either a) or b) administered separately. |
2. A method for the treatment of high blood pressure, which comprises administering to a host in recognized need thereof an effective amount of a pharmaceutical composition as claimed in claim 1.
3. A method for the treatment of cardiac insufficiency, which comprises administering to a host in recognized need thereof an effective amount of a pharmaceutical composition as claimed in claim 1.
4. A method for the treatment of coronary heart disease, which comprises administering to a host in recognized need thereof an effective amount of a pharmaceutical composition as claimed in claim 1.
5. A pharmaceutical composition as claimed in claim 1, wherein said composition comprises a physiologically acceptable carrier.
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