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|Title:||Plaque inhibition with antiplaque oral composition dispensed from container having polymeric material in contact and compatible with the composition|
|Abstract:||An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.|
|Inventor(s):||Gaffar; Abdul (Princeton, NJ), Robinson; Richard S. (Piscataway, NJ), Miller; Jeffrey (Sayreville, NJ), Potini; Chimpiramma (East Brunswick, NJ), Collins; Michael A. (Keyport, NJ), Shackil; Theresa G. (Vincentown, NJ)|
|Assignee:||Colgate Palmolive Company (Piscataway, NJ)|
|Filing Date:||Jan 10, 1994|
|Claims:||1. In a method of inhibiting plaque on teeth comprising applying to the teeth an oral composition dispensed from an article comprising a dispensing container having solid polymeric material in contact with an oral composition in the container, which composition comprises an effective antibacterial antiplaque proportion of a substantially water insoluble non-cationic halogenated diphenyl ether antibacterial antiplaque agent which is normally so incompatible with said solid polymeric material that at least about 25% of said agent is lost after six weeks storage at room temperature in said container, the improvement comprising employing as said solid polymeric material polytetrafluoroethylene which is compatible with said agent in the presence of the oral composition whereby said loss is prevented and the dispensed composition contains more than about 75% of its initial content of said agent. |
2. A method according to claim 1 in which the composition is a toothpaste, gel or liquid dentifrice, a liquid mouthwash, or a paste, gel or liquid tooth treating agent and the container is a deformable dispensing tube, a pump dispenser, a pressurized dispenser, or a sachet for toothpaste, gel dentifrice, or paste or gel tooth treating agent, or a bottle or other container for a liquid dentifrice, mouthwash or tooth treating agent.
3. A method according to claim 1 in which the composition is a toothpaste, gel dentifrice or liquid mouthwash, and wherein the halogenated diphenyl ether antibacterial agent comprises a diphenyl ether substituted with 1 to 3 hydroxyls and 1 to 4 halogens selected from the group consisting of chlorine and bromine, and the container is a deformable dispensing tube, a pump dispenser or a sachet for the toothpaste or gel dentifrice, or a bottle or other dispensing container for the liquid mouthwash.
4. A method according to claim 1 wherein said composition comprises 0.1 to 7% of a linear molecularly dehydrated polyphosphate antitartar agent.
5. A method according to claim 1 wherein the halogenated diphenyl ether antibacterial agent of said composition comprises 2',4,4'-trichloro-2-hydroxy-diphenyl ether (THDE) or 2,2'-dihydroxy-5',5'-dibromo-diphenyl ether (DDDE).
6. A method according to claim 1 wherein the halogenated diphenyl ether antibacterial agent comprises THDE.
7. A method according to claim 1 in which the composition comprises 0.02 to 1% of THDE and/or DDDE.
8. A method according to claim 1 in which the composition comprises 0.03 to 0.6% of THDE.
9. A method according to claim 4 in which the polyphosphate comprises a pyrophosphate.
10. A method according to claim 1 in which the composition is a toothpaste or gel dentifrice containing 0.25 to 0.5% of THDE in a deformable dispensing tube, a pump dispenser or a sachet.
11. A method according to claim 1 in which the composition comprises 1 to 25% of alkali metal pyrophosphate.
12. A method according to claim 1 in which the composition is a toothpaste or gel dentifrice containing about 0.02 to 1% of THDE and 0.1 to 3% of sodium pyrophosphate, and the container is a deformable dispensing tube or a pump dispenser.
13. A method according to claim 1, the composition of which comprises 0.5 to 4% of a synthetic anionic polymeric polycarboxylate.
14. A method according to claim 1, in which the oral composition comprises 1 to 2.5% of sodium phyrophosphate and 2 to 3% of polyvinyl methyl ether/maleic anhydride copolymer.
15. A method according to claim 1, in which the oral composition comprises 0.1 to 3% of linear molecularly dehydrated polyphosphate and 0.2 to 5% of synthetic anionic polymeric polycarboxylate.
16. A method according to claim 4 in which the composition comprises about 0.02 to 1% of THDE.
17. A method according to claim 1 wherein the container is opaque.
18. In a method of inhibiting plaque on teeth comprising applying an oral antiplaque toothpaste or gel dentifrice composition to the teeth with a toothbrush, the step of applying to the toothbrush about 0.8 to 2 grams of such oral composition dispensed from an article comprising a dispensing container having solid polytetrafluoroethylene polymeric material in contact with said oral composition in the container, which composition comprises an effective antibacterial antiplaque proportion of THDE antibacterial antiplaque agent, and said polymeric material is so compatible with said agent in the presence of the oral composition that less than about 25% of the initial content of said agent is lost after six weeks storage at room temperature in said container.
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