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|Title:||Surface modified anticancer nanoparticles|
|Abstract:||Dispersible particles consisting essentially of a crystalline anticancer agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm. Anticancer compositions comprising the particles exhibit reduced toxicity and/or enhanced efficacy, and can be administered by IV bolus injection.|
|Inventor(s):||Liversidge; Gary G. (West Chester, PA), Liversidge; Elaine (West Chester, PA), Sarpotdar; Pramod P. (Malvern, PA)|
|Assignee:||Eastman Kodak Company (Rochester, NY)|
|Filing Date:||Dec 28, 1994|
|Claims:||1. Particles consisting essentially of a crystalline piposulfan having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an average effective particle size of less than 1000 nm. |
2. The particles of claim 1 wherein said surface modifier comprises in combination a polyoxyethylene sorbitan fatty acid ester and a sorbitan ester of a fatty acid; wherein the fatty acid contains 12 to 18 carbon atoms.
3. The particles of claim 1 wherein said surface modifier is polyvinyl alcohol.
4. The particles of claim 1 wherein said surface modifier is gum acacia.
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