|Title:||Catechol derivatives, their physiologically acceptable salts, esters and use|
|Abstract:||Known and new catechol derivates may be used as medicinal antioxidants in the prevention or treatment of tissue damage induced by lipid peroxidation. The conditions and diseases to be treated are for example heart disease, rheumatoid arthritis, cancer, inflammatory disease, a rejection reaction in organ transplants, ischemia, cancer and aging.|
|Inventor(s):||Korkolainen; Tapio J. (Helsinki, FI), Nissinen; Erkki A. O. (Espoo, FI), Backstrom; Reijo J. (Helsinki, FI), Pippuri; Aino K. (Espoo, FI)|
|Assignee:||Orion-yhtyma Oy (Espoo, FI)|
|Filing Date:||Jun 05, 1995|
|Claims:||1. A method for the prevention or treatment of tissue damage induced by lipid peroxidation associated with ischemia by administering to a patient in need of such prevention or treatment an effective amount to prevent or treat tissue damage induced by lipid peroxidation of the compound of formula I ##STR11## wherein R.sub.3 is cyano or lower acyl and R.sub.4 is lower acyl or carbamoyl which is unsubstituted or substituted by lower alkyl or lower hydroxyalkyl or a physiologically acceptable salt or ester thereof. |
2. The method according to claim 1, in which the compound is 3-(3,4-dihydroxy-5-nitrophenyl)methylene-2,4-pentanedione.