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Generated: August 21, 2017
| Title: | Anti-aids piperazines |
| Abstract: | The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X). |
| Inventor(s): | Palmer; John R. (Kalamazoo, MI), Aristoff; Paul A. (Kalamazoo, MI), Romero; Donna L. (Kalamazoo, MI) |
| Assignee: | The Upjohn Company (Kalamazoo, MI) |
| Filing Date: | Dec 02, 1994 |
| Application Number: | 08/349,694 |
| Claims: | 1. An anti-AIDS piperazine (IV) selected from the group consisting of 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine, 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piper azine, 1-[5-hydroxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine, 1-[5-hydroxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piper azine, 1-[5-methoxy-4,6,7-trimethylindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridin yl]piperazine, 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(1,1-dimethylethylamino)-2-pyridinyl]p iperazine, 1-(5-methoxyindolyl-2-carbonyl)-4-[3-(methylamino)-2-pyridinyl]piperazine, 1-[5-methoxyindolyl-2-methyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine, 1-(5-methoxyindolyl-2-carbonyl)-4-[3-methylamino-2-pyridinyl]piperazine, 1-(5-methoxyindolyl-2-carbonyl)-4-[3-propylamino-2-pyridinyl]piperzine, 1-(5-methoxyindolyl-2-carbonyl)-4-[3-(cyclo-propylmethylamino)-2-pyridinyl] piperazine, and enantiomers, pharmaceutically acceptable salts, hydrates and solvates thereof. 2. An anti-AIDS piperazine (IV) according to claim 1 which is 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine, 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piper azine, 1-[5-hydroxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piper azine, 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(1,1-dimethylethylamino)-2-pyridinyl]p iperazine, 1-(5-methoxyindolyl-2-carbonyl)-4-[3-(methylamino)-2-pyridinyl]piperazine. 3. An anti-AIDS piperazine (IV) according to claim 1 which is 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine. 4. An anti-AIDS piperazine (IV) according to claim 3 which is 1-[5-methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine mesylate. |
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