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|Title:||1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and analogues|
|Abstract:||Novel 1.alpha.-hydroxy Vitamin D.sub.4 and novel analogues, 1,25 dihydroxy Vitamin D.sub.4 and 1,24 dihydroxy Vitamin D.sub.4 which are useful for the treatment of disorders of calcium metabolism. Preparation of the novel 1.alpha.-hydroxy Vitamin D.sub.4 starts from ergosterol which is converted in six steps to 22,23-dihydroergosterol. 22,23-dihydroergosterol was irradiated to yield Vitamin D.sub.4 which was converted in four steps to 1.alpha.-hydroxy Vitamin D.sub.4 using a cyclovitamin procedure which produced the novel intermediates, Vitamin D.sub.4 tosylate, 3,5 cyclovitamin D.sub.4 and 1.alpha.-hydroxy cyclovitamin D.sub.4. 1,25 dihydroxy Vitamin D.sub.4 and 1,24 dihydroxy Vitamin D.sub.4 are isolated as biological products of the metabolism of novel 1.alpha.-hydroxy Vitamin D.sub.4 using cultured human liver cells.|
|Inventor(s):||Knutson; Joyce C. (Madison, WI), Bishop; Charles W. (Verona, WI), Moriarty; Robert M. (Oak Park, IL)|
|Assignee:||Lunar Corporation (Madison, WI)|
|Filing Date:||Aug 24, 1994|
|Claims:||1. 1.alpha.-hydroxy Vitamin D.sub.4.|
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