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Details for Patent: 5,474,982

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Details for Patent: 5,474,982

Title: PDGF analogs and methods of use
Abstract:Proteins having substantially the same biological activity as PDGF are provided. In one aspect, a protein homodimer having two polypeptide chains is disclosed, each of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- and B-chains of PDGF, the protein being chemotactic or mitogenic for fibroblasts. Therapeutic compositions comprising such proteins in combination with a physiologically acceptable carrier or diluent are also provided. Such therapeutic compositions may be used within methods for enhancing the wound-healing process in warm-blooded animals.
Inventor(s): Murray; Mark J. (Seattle, WA), Kelly; James D. (Seattle, WA)
Assignee: ZymoGenetics, Inc. (Seattle, WA)
Filing Date:Jul 12, 1994
Application Number:08/273,779
Claims:1. An unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts.

2. A therapeutic composition comprising an unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B- chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier or diluent.

3. A method for enhancing the wound-healing process in warm-blooded animals, comprising administering to the animal a therapeutically effective amount of a composition comprising an unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier.

4. The method of claim 3 wherein said carrier is selected from the group consisting of albumin, sterile water, polyethylene glycol and saline.

5. The method of claim 3 wherein said composition includes an adjuvant.

6. The method of claim 3 wherein said composition is administered topically.

7. The method of claim 3 wherein said composition is administered in a dose of from about 0.5 to about 10 .mu.g per cm.sup.2 of wound area.

8. The method of claim 3 wherein said composition includes an effective amount of basic fibroblast growth factor.

9. The method of claim 8 wherein the protein homodimer and the fibroblast growth factor are present in a ratio of from approximately 1 to 0.4, to 10 to 0.4, respectively.

10. The method of claim 3 wherein said warm-blooded animal is a diabetic animal.
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