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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Healthtrust
Teva
Daiichi Sankyo
US Army
Cipla
US Department of Justice
McKesson
Merck

Generated: April 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,472,841

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Title: Methods for identifying nucleic acid ligands of human neutrophil elastase
Abstract:Methods are described for the identification and preparation of nucleic acid ligands to human neutrophil elastase. Included in the invention are specific RNA and DNA ligands to elastase identified by the SELEX method.
Inventor(s): Jayasena; Sumedha D. (Boulder, CO), Gold; Larry (Boulder, CO)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Filing Date:Feb 22, 1994
Application Number:08/199,507
Claims:1. A method for identifying nucleic acid ligands to elastase, comprising:

a) contacting a candidate mixture of nucleic acids with elastase, wherein nucleic acids having an increased affinity to elastase relative to the candidate mixture nucleic acids may be partitioned from the remainder of the candidate mixture;

b) partitioning the increased affinity nucleic acids from the remainder of the candidate mixture; and

c) amplifying the increased affinity nucleic acids to yield a ligand-enriched mixture of nucleic acids, whereby nucleic acid ligands to elastase may be identified.

2. The method of claim 1 wherein said candidate mixture of nucleic acids is comprised of single stranded nucleic acids.

3. The method of claim 2 wherein said single stranded nucleic acids are ribonucleic acids.

4. The method of claim 2 wherein said single stranded nucleic acids are 2'-amino-2'-deoxypyrimidine modified ribonucleic acids.

5. The method of claim 2 wherein said single stranded nucleic acids are deoxyribonucleic acids.

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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Daiichi Sankyo
Healthtrust
Federal Trade Commission
Express Scripts
Covington
Dow
Farmers Insurance
McKinsey

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