.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,466,437

« Back to Dashboard

Details for Patent: 5,466,437

Title: Antibacterial antiplaqued oral composition mouthwash or liquid dentifrice
Abstract:An oral composition mouthwash or liquid dentifrice containing an aqueous vehicle acceptable vehicle, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (No. Brunswick, NJ), Afflitto; John (Brookside, NJ), Stringer; Orum (Yardley, PA)
Assignee: Colgate Palmolive Company (Piscataway, NJ)
Filing Date:Dec 03, 1993
Application Number:08/161,013
Claims:1. Oral composition mouthwash or liquid dentifrice comprising an aqueous vehicle, an effective antiplaque amount of a substantially water insoluble noncationic antibacterial agent, said oral composition comprising at least one of a surface active agent, a flavoring oil and a non-toxic alcohol and about 0.005-4% by weight of an antibacterial-enhancing agent having an average molecular weight of about 100 to 1,000,000 which contains at least one carboxylic delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said oral composition mouthwash or liquid dentifrice is free of polyphosphate anticalculus agent in an effective anticalculus amount.

2. The oral composition claimed in claim 1 wherein said antibacterial agent is selected from the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benzoic esters, halogenated carbanilides and phenolic compounds.

3. The oral composition claimed in claim 2 wherein said antibacterial agent is a halogenated diphenyl ether.

4. The oral composition mouthwash or liquid dentifrice claimed in claim 3 wherein said halogenated diphenyl ether is 2,4,4'-trichloro-2'-hydroxyphenyl ether.

5. The oral composition mouthwash or liquid dentifrice claimed in claim 2 wherein said antibacterial agent is a phenolic compound.

6. The oral composition mouthwash or liquid dentifrice claimed in claim 5 wherein said phenolic compound is selected from the group consisting of phenol, thymol, eugenol and 2,2'-methylene bis (4-chloro-6-bromophenol).

7. The oral composition mouthwash or liquid dentifrice claimed in any of claims 1 to 6 wherein said antibacterial agent is present in amount of about 0.01-5% by weight.

8. The oral composition mouthwash or liquid dentifrice claimed in claim 7 wherein said amount of antibacterial agent is about 0.25-0.5%.

9. The oral composition claimed in any of claims 1 to 6 wherein said composition is a mouthwash and said aqueous vehicle contains a non-toxic alcohol and the weight ratio of water to non-toxic alcohol is from about 1:1 to about 20:1.

10. The oral composition mouthwash claimed in claim 9 wherein said non-toxic alcohol is ethanol.

11. The oral composition claimed in any of claims 1 to 6 wherein said oral composition is a liquid dentifrice.

12. The oral composition liquid dentifrice claimed in claim 11 wherein said liquid dentifrice contains about 0.3-2.0% by weight of a polysaccharide of high molecular weight in excess of 1,000,000 containing mannose, glucose, potassium glucuronate and acetyl moieties in the approximate ratio of 2:1:1:1, as suspending and thickening agent.

13. The oral composition liquid dentifrice claimed in claim 12 wherein said liquid dentifrice contains about 10-20% by weight of a polishing material.

14. The oral composition mouthwash or liquid dentifrice claimed in any of claims 1 to 6 wherein said surface active agent is present in amount of about 0.5-5% by weight.

15. The oral composition mouthwash or liquid dentifrice claimed in any of claims 1 to 6 wherein said flavoring oil is present in amount of about 0.1-5% by weight.

16. The oral composition claimed in claim 15 wherein said organic retention-enhancing group comprises the formula --(X).sub.n --R wherein X is O, N, S, SO, SO.sub.2, P, PO or Si, R is hydrophobic alkyl, aryl, alkaryl, alkenyl, acyl, aralkyl, heterocyclic, or inert-substituted derivatives thereof, and n is zero or 1 or more and wherein said antibacterial-enhancing agent is a natural or synthetic monomer or a polymer selected from a group consisting of oligomers, homopolymers, copolymers of two or more monomers, ionomers, block copolymers, graft copolymers and cross-linked polymers and monomers.

17. The oral composition claimed in claim 16 wherein said antibacterial-enhancing agent is a carboxylic polymer containing a plurality of said delivery-enhancing and retention-enhancing groups.

18. The oral composition according to claim 17 wherein said carboxylic polymer comprises a chain containing repeating units each containing at least one carbon atom.

19. The oral composition claimed in claim 18 wherein the unit contains at least one carboxylic delivery-enhancing group and at least one retention-enhancing group bonded to the same, vicinal, or other atoms in the chain.

20. Oral composition mouthwash or liquid dentifrice comprising an aqueous vehicle, an effective antiplaque amount of a substantially water insoluble noncationic antibacterial agent, said oral composition comprising at least one of a surface active agent, a flavoring oil and a non-toxic alcohol and about 0.005-4% by weight of an anionic copolymer of maleic acid or anhydride with another ethylenically unsaturated polymerizable monomer, which copolymer enhances delivery and attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said oral composition is free of polyphosphate anticalculus agent in an effective anticalculus amount.

21. The oral composition claimed in claim 20 wherein said other monomer of said copolymer is methyl vinyl ether in a 4:1 to 1:4 molar ratio with the maleic acid or anhydride.

22. The oral composition claimed in either of claims 20 or 21 wherein said copolymer has a molecular weight of about 30,000-1,000,000.

23. The oral composition claimed in claim 22 wherein the copolymer has an average molecular weight of about 70,000.

24. Oral composition mouthwash or liquid dentifrice comprising an aqueous vehicle, about 0.01-5% of triclosan, at least one member of the group consisting of surface active agents, flavoring oils and non-toxic alcohols, and about 0.05-4% of a copolymer of maleic acid or anhydride with methyl vinyl ether, said composition being free of polyphosphate anticalculus agent in an effect anticalculus amount.

25. The oral composition claimed in any of claims 1 to 6 or 20 to 24 containing a fluoride-providing source.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc