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Details for Patent: 5,453,265

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Details for Patent: 5,453,265

Title: Antibacterial antiplaque oral composition
Abstract:An oral composition dentifrice containing an orally acceptable vehicle, about 30-75% by weight of a dentally acceptable water-insoluble polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) an antibacterial enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, and a surface active agent and/or a flavoring oil.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (No. Brunswick, NJ), Afflitto; John (Brookside, NJ), Stringer; Drum (Yardley, PA), Prencipe; Michael (East Windsor, NJ)
Assignee: Colgate Palmolive Company (Piscataway, NJ)
Filing Date:Jan 13, 1994
Application Number:08/181,525
Claims:1. An oral composition dentifrice for attaching, adhering or bonding a plaque-inhabiting antibacterial agent to oral tooth and gum surfaces comprising in an orally acceptable aqueous humectant vehicle about 30-75% by weight of a dentally acceptable water insoluble polishing agent, an effective antiplaque amount in the range of about 0.01-5% by weight of a substantially water insoluble non-cationic antibacterial agent, at least one of a surface active agent or a flavoring oil and an effective amount in the range of about 0.05-4% by weight of an antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, which delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said oral composition is free of polyphosphate anticalculus agent in an effective anticalculus amount and said vehicle is other than polyethylene glycol which reduces the antibacterial activity of said antibacterial agent.

2. The oral composition claimed in claim 1, wherein said antibacterial agent is selected from the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benzoic esters, halogenated carbanilides and phenolic compounds.

3. The oral composition claimed in claim 2, wherein said antibacterial agent is a halogenated diphenyl ether.

4. The oral composition claimed in claim 3, wherein said halogenated diphenyl ether is 2,4,4'-trichloro-2'-hydroxydiphenyl ether.

5. The oral composition claimed in claim 2, wherein said antibacterial agent is a phenolic compound.

6. The oral composition claimed in claim 5, wherein said phenolic compound is selected from the group consisting of phenol, thymol, eugenol, and 2,2'-methylene bis (4-chloro-6-bromophenol).

7. The oral composition claimed in claim 1, wherein said antibacterial agent is present in amount of about 0.25-5% by weight.

8. The oral composition claimed in any one of claims 1-7, wherein said polishing agent is selected from the group consisting of sodium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium phosphate, calcium carbonate, aluminum silicate, hydrated alumina, silica, bentonite, and mixtures thereof.

9. The oral composition dentifrice claimed in claim 8, wherein said polishing agent is dicalcium phosphate dihydrate.

10. The oral composition dentifrice claimed in claim 8, wherein said polishing agent is hydrated alumina.

11. The oral composition claimed in any one of claims 1-7, wherein said surface active agent is present in amount of about 0.5.5% by weight.

12. The oral composition dentifrice claimed in claim 11, wherein said surface active agent is present in amount of about 1-2.5% by weight.

13. The oral composition dentifrice claimed in claim 1, wherein said antibacterial-enhancing agent is water soluble or swellable.

14. The oral composition claimed in claim 13, wherein said antibacterial-enhancing agent has an average molecular weight of about 100 to about 1,000,000.

15. The oral composition claimed in claim 14, wherein said delivery-enhancing group is acidic.

16. The oral composition claimed in claim 15, wherein said delivery-enhancing group is selected from the group consisting of carboxylic, phosphinic and sulfonic acids, and their salts, and mixtures thereof, and wherein said organic retention-enhancing group comprises the formula --(X).sub.n --R wherein X is O, N, S, SO, SO.sub.2, P, PO or Si, R is hydrophobic alkyl, alkenyl, acyl, aryl, alkaryl, aralkyl, heterocyclic, or their inert-substituted derivatives, and n is zero or one or more, and wherein said antibacterial-enhancing agent is a monomer or polymer selected from the group consisting of oligomers, homopolymers, copolymers of two or more monomers, ionomers, block copolymers, graft copolymers, and crosslinked polymers and monomers.

17. The oral composition claimed in claim 16, wherein said antibacterial-enhancing agent is an anionic polymer containing a plurality of said delivery-enhancing and retention-enhancing groups.

18. The oral composition claimed in claim 17, wherein said anionic polymer comprises a chain containing repeating units each containing at least one carbon atom.

19. The oral composition claimed in claim 18, wherein each unit contains at least one delivery-enhancing group and at least one organic retention-enhancing group and at least one organic retention-enhancing group bonded to the same or vicinal or other atoms in the chain.

20. The oral composition claimed in claim 16, wherein the delivery-enhancing group is a carboxylic group salt thereof.

21. The oral composition dentifrice for attaching, adhering or bonding a plaque-inhibiting antibacterial agent to oral tooth and gum surfaces comprising an orally acceptable aqueous humectant vehicle, about 30-70% by weight of a dentally acceptable water insoluble polishing agent, an effective amount in the range of 0.01-5% by weight of a substantially water insoluble non-cationic antibacterial agent, at least one of surface active agent or a flavoring oil and an effective amount in the range of about 0.05-4% by weight of an anionic copolymer of maleic acid or anhydride with another ethylenically unsaturated polymerizable monomer, which copolymer enhances delivery and attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said oral composition is free of polyphosphate anticalculus agent in an effective anticalculus amount and said vehicle is other than polyethylene glycol which reduces the antibacterial activity of said antibacterial agent.

22. The oral composition according to claim 21, wherein said other monomer of said copolymer is methyl vinyl ether in a 4:1 to 1:4 molar ratio with the maleic acid or anhydride.

23. The oral composition according to claim 22, wherein said copolymer has a molecular weight of about 30,000-1,000,000 and is present in amount of about 0.1-2% by weight.

24. A composition according to claim 23, wherein the copolymer has an average molecular weight of about 70,000.

25. The oral composition claimed in claim 21, wherein said antibacterial agent is selected from the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benzoic ester, halogenated carbanilides, and phenolic compounds.

26. A composition according to any one of claims 1-7 and 13-25 containing an effective anticaries amount of a fluoride ion-providing source.
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