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Details for Patent: 5,411,952

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Details for Patent: 5,411,952

Title: Ocular cyclosporine composition
Abstract:Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye, containing cyclosporine dissolved in corn oil. The composition may further include antioxidants, lubricants, antibiotics, antifungals, antivirals, pilocarpine, vasoconstrictors, surfactants, wetting agents, anti-inflammatory agents (i.e. corticosteroids), preservatives, mucolytic agents (i.e. bromhexine, acetylcysteine), as well as other compounds. The preferred composition is 2% cyclosporine, 1 mole % alpha tocopherol and 0.005% methyl paraben in corn oil.
Inventor(s): Kaswan; Renee (Athens, GA)
Assignee: University of Georgia Research Foundation, Inc. (Atlanta, GA)
Filing Date:Feb 06, 1990
Application Number:07/474,683
Claims:1. A topical ophthalmic composition comprising a pharmaceutically effective amount of cyclosporin in corn oil.

2. The composition of claim 1 wherein the concentration of cyclosporine is between about 0.01% and saturation.

3. The composition of claim 1 further comprising a compound selected from the group consisting of vitamin A, vitamin E, retinoic acid, pilocarpine, hyaluronic acid, polyvinyl alcohol, methylcellulose, methyl paraben, eledoisin, physalaemin, bromhexine, mucosolvan, acetylcysteine, indomethacin, and corticosteroids.

4. The composition of claim 1 comprising 2% cyclosporine in corn oil.

5. The composition of claim 4 further comprising a compound selected from the group consisting of alpha tocopherol and methyl paraben.

6. The composition of claim 1 wherein said composition is encapsulated.

7. The composition of claim 6 wherein said composition is encapsulated within a polymeric matrix.

8. The composition of claim 7 wherein said composition is encapsulated within a polymeric matrix formed of a polymer selected from the group consisting of polyethylene, polystyrene, polypropylene, polyanhydrides, polyorthoester, polylactic acid, and polyglycolic acid.

9. The composition of claim 6 wherein said composition is encapsulated within liposomes.

10. The composition of claim 6 wherein said composition is microencapsulated.

11. The composition of claim 1 wherein said cyclosporine is in a concentration which stimulates or restores lacrimal gland activity.

12. The composition of claim 1 wherein said cyclosporine is in a concentration which suppresses an immune disorder of the eye.
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