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Details for Patent: 5,403,831

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Details for Patent: 5,403,831

Title: Method of treating and preventing loss of bone mass using 1.alpha.-hydroxy-vitamin D.sub.2
Abstract:A method for reversing loss of bone mass or bone mineral content in a human being suffering from osteoporosis is disclosed which comprises administering to the human being a daily dosage of at least 2.0 micrograms/day of 1-alpha-hydroxy-Vitamin D.sub.2.
Inventor(s): DeLuca; Hector F. (Deerfield, WI), Bishop; Charles W. (Verona, WI), Mazess; Richard B. (Madison, WI), Gallagher; John C. (Omaha, NE)
Assignee: Bone Care International, Inc. (Madison, WI)
Filing Date:Sep 10, 1993
Application Number:08/119,895
Claims:1. A method for preventing loss of bone mass or bone mineral content in post menopausal women, comprising: administering to said human an amount of 1.alpha. hydroxy vitamin D.sub.2 sufficient to prevent loss of bone mass or bone mineral content without causing hypercalcemia or hypercalciura.

2. The method of claim 1, wherein said compound is administered parenterally.

3. The method of claim 2, wherein said compound is administered parentally by subcutaneous, intramuscular, or intravenous injection, nasopharyngeal or mucosal absorption, or transdermal absorption.

4. The method of claim 1, wherein said compound is administered orally.

5. The method of claim 1, wherein said compound is administered at a dosage of about 2.0 mg daily.

6. The method of claim 1, wherein said compound is administered at a dosage of about 2.5 mg daily.

7. The method of claim 1, wherein said compound is administered at a dosage of about 3.0 mg daily.

8. The method of claim 1, wherein said compound is administered at a dosage of about 4.0 mg daily.

9. A method for preventing loss of bone mass or bone mineral content in a post menopausal woman, said method comprising the steps of:

a. maintaining a calcium intake in said woman of between 250 to 2500 mg/day;

b. administering daily to said woman an amount of 1.alpha.hydroxyergocalciterol sufficient to prevent loss of bone mass or bone mineral content without causing hypercalciuria or hypercalcernia.
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