Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Substituted pyridines heptenoic acid derivatives, useful for treating arterioscleros, lipopotaemia and the like|
|Abstract:||Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings, X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and R is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl and R.sup.22 --denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products.|
|Inventor(s):||Angerbauer; Rolf (Wuppertal, DE), Fey; Peter (Wuppertal, DE), Hubsch; Walter (Wuppertal, DE), Philipps; Thomas (Cologne, DE), Bischoff; Hilmar (Wuppertal, DE), Petzinna; Dieter (Duesseldorf, DE), Schmidt; Delf (Wuppertal, DE), Thomas; Gunter (Arese, IT)|
|Assignee:||Bayer Aktiengesellschaft (Leverkusen, DE)|
|Filing Date:||Jul 20, 1992|
|Claims:||1. A substituted pyridine of the formula: ##STR234## wherein A represents phenyl or phenyl which is monosubstituted or disubstituted by a substituent selected from the group consisting of methyl, hydroxymethyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, methoxy, ethoxy, propoxy, isopropoxy, phenoxy, benzyloxy, fluorine, chlorine or trifluoromethyl; |
B represents cyclopropyl, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, or tert.-butyl;
E represents methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, pentyl, isopentyl, hexyl or isohexyl; and
R.sup.22 represents hydrogen, lower alkyl, phenyl, benzyl or a physiologically tolerable metal or ammonium cation.
2. A compound according to claim 1, wherein such compound is erythro-(E)-7-[2-(4-fluorophenyl)-5-hydroxymethyl-4-isopropyl-6-methyl-pyr id-3-yl]-3,5-dihydroxy-hept-6-enoate of the formula: ##STR235##
3. A compound according to claim 1, wherein such compound is erythro-(E)-7-[2-(4-fluorophenyl)-5-hydroxymethyl-4,6-diisopropyl-pyridin- 3-yl]-3,5-dihydroxy-hept-6-enoate of the formula: ##STR236##
4. A composition for inhibiting cholesterol biosynthesis and HMG-CoA reductase comprising an amount effective therefor of a compound according to claim 1 and a pharmaceutically acceptable diluent.
5. A method of treating a patient afflicted with hyperlipoproteinaemia, lipoproteinaemia or arteriosclerosis which comprises administering to such patient an amount effective therefor of a compound according to claim 1.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.