|Title:||Indolyl tetrahydropyridines for treating migraine|
|Inventor(s):||Robertson; Alan D. (Beckenham, GB2), Hill; Alan P. (Beckenham, GB2), Glen; Robert C. (Beckenham, GB2), Martin; Graeme R. (Beckenham, GB2)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
|Filing Date:||Mar 03, 1992|
|Claims:||1. A compound of the formula: ##STR37## wherein n is an integer of from 0 to 3; |
W is a group of formula (i), (ii), or (iii) ##STR38## wherein R is hydrogen or C.sub.1-4 alkyl, X is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral center * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and
Z is a group of the formula: ##STR39## wherein R.sup.3 is hydrogen or C.sub.1-4 alkyl; its solvate or a physiologically acceptable salt thereof.
2. A method of preventing or treating migraine comprising administering to a patient in need of same an effective amount of a compound of claim 1 or a physiologically acceptable salt or solvate thereof.
3. The method as claimed in claim 2 in which the patient is a human.
4. A pharmaceutical composition comprising an effective amount of the compound of claim 1 or a physiologically acceptable salt or solvate thereof together with a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4 which is in the form of a tablet or capsule.