Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Indolyl tetrahydropyridines for treating migraine|
|Inventor(s):||Robertson; Alan D. (Beckenham, GB2), Hill; Alan P. (Beckenham, GB2), Glen; Robert C. (Beckenham, GB2), Martin; Graeme R. (Beckenham, GB2)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
|Filing Date:||Mar 03, 1992|
|Claims:||1. A compound of the formula: ##STR37## wherein n is an integer of from 0 to 3; |
W is a group of formula (i), (ii), or (iii) ##STR38## wherein R is hydrogen or C.sub.1-4 alkyl, X is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral center * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and
Z is a group of the formula: ##STR39## wherein R.sup.3 is hydrogen or C.sub.1-4 alkyl; its solvate or a physiologically acceptable salt thereof.
2. A method of preventing or treating migraine comprising administering to a patient in need of same an effective amount of a compound of claim 1 or a physiologically acceptable salt or solvate thereof.
3. The method as claimed in claim 2 in which the patient is a human.
4. A pharmaceutical composition comprising an effective amount of the compound of claim 1 or a physiologically acceptable salt or solvate thereof together with a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4 which is in the form of a tablet or capsule.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.